4-Hydroxyphenylboronic acid, identified by CAS 71597-85-8, is an aromatic boronic acid used mainly as a building block for organic synthesis, especially palladium-catalyzed Suzuki–Miyaura coupling. Its molecular formula is C6H7BO3, and its relative molecular mass is approximately 137.93 g/mol. The molecule contains both a boronic acid group and a para-hydroxyl group, giving it useful reactivity for carbon–carbon bond formation and further functionalization.
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In this guide, I explain the compound’s core properties, common application areas, handling considerations, specification points, and the supplier questions that help buyers reduce sourcing risk. At Maison Chemical, we support customers evaluating 4-Hydroxyphenylboronic acid for research, process development, and commercial synthesis applications.
This guide is intended for pharmaceutical and agrochemical research teams, specialty chemical manufacturers, process chemists, purchasing departments, and distributors sourcing aromatic boronic acids. It is also useful for laboratories comparing different grades or assessing whether a supplier can support repeat orders. The information is written for technical and commercial evaluation rather than as a replacement for a product-specific safety data sheet.
Buyers should confirm the intended reaction, required purity, packaging format, storage conditions, and regulatory documentation before placing an order. These details can affect the suitable grade, available quantity, lead time, and total procurement cost. Where a specific product specification is required, I recommend requesting the current batch documentation from the supplier.
4-Hydroxyphenylboronic acid is an organoboron compound in which a boronic acid group is attached to a phenyl ring bearing a hydroxyl group at the para position. The boronic acid functionality can participate in cross-coupling reactions, while the phenolic hydroxyl group provides an additional site for derivatization or intermolecular interaction. This combination makes the compound more versatile than a simple unsubstituted phenylboronic acid in some synthetic routes.
The material is commonly handled as a solid chemical intermediate. Its appearance, particle size, water content, and assay should be confirmed from the supplier’s current specification because these characteristics may vary by manufacturing route, purification method, and packaging conditions. I advise customers not to rely solely on catalog descriptions when the compound will be used in a regulated or scale-sensitive process.
| Item | Reference information | Buyer relevance |
|---|---|---|
| Common name | 4-Hydroxyphenylboronic acid | Used for product identification and technical communication |
| CAS number | 71597-85-8 | Helps distinguish the target compound from positional isomers |
| Molecular formula | C6H7BO3 | Supports stoichiometric calculations and substance verification |
| Relative molecular mass | Approximately 137.93 g/mol | Used to calculate molar quantities and reaction equivalents |
| Functional groups | Aryl boronic acid and phenolic hydroxyl | Determines coupling and downstream derivatization potential |
Because boronic acids can interact with moisture and undergo condition-dependent chemical changes, I recommend reviewing water content and stability requirements for each process. Solubility is also solvent- and temperature-dependent, so laboratory users should verify the compound’s behavior in their selected reaction medium rather than assuming complete dissolution. A small-scale compatibility check is appropriate when changing supplier, solvent system, or process concentration.
The most established use of 4-Hydroxyphenylboronic acid is as an arylboronic acid partner in Suzuki–Miyaura coupling. In a suitable catalytic system, the arylboronic acid can react with an aryl or heteroaryl halide to form a biaryl structure. The phenolic group remains available for additional transformation, protection, or incorporation into the final molecule.
Reaction performance depends on the coupling partner, catalyst, base, solvent, temperature, concentration, and work-up procedure. Therefore, the compound should be selected as part of the complete reaction design rather than judged independently. Buyers developing a new route may need both analytical-grade material for screening and a consistent production grade for scale-up.
The para-hydroxyl and boronic acid groups provide two chemically useful handles for building substituted aromatic intermediates. Research chemists may use the material to prepare biaryl compounds, oxygen-containing aromatic structures, and molecules requiring controlled substitution around a phenyl ring. Its value is generally highest when the synthesis needs a defined para relationship between the hydroxyl and boronic acid functionalities.
It is important to distinguish use as a synthetic intermediate from use as an active pharmaceutical ingredient. 4-Hydroxyphenylboronic acid is normally evaluated as a raw material or intermediate, and its suitability for a pharmaceutical process must be established through the customer’s own route, impurity profile, and quality requirements.
Boronic acids are also studied in molecular recognition, sensor research, and carbohydrate-related binding systems because boron-containing groups can interact reversibly with suitable diols under appropriate conditions. The exact behavior depends strongly on pH, solvent, substituent effects, and molecular design. For this reason, I recommend treating these uses as application-specific research areas and validating performance experimentally.
In sourcing discussions, the key distinction is usually not a different chemical identity but the required quality profile and supply format. A laboratory may require a small pack with a defined assay and analytical data, while a manufacturing customer may prioritize lot consistency, controlled packaging, and repeat availability. The appropriate specification should be linked to the customer’s reaction sensitivity and downstream quality requirements.
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| Specification area | What to confirm |
|---|---|
| Assay | Minimum assay requirement and analytical method used |
| Water content | Whether moisture control is necessary for the intended reaction |
| Impurity profile | Residual starting materials, positional isomers, inorganic residues, and process-related impurities |
| Particle and packaging format | Pack size, container type, sealing method, and protection during transport |
| Documentation | Certificate of analysis, safety data sheet, specification sheet, and batch traceability |
When a customer has a sensitive coupling reaction, I suggest comparing more than the headline assay. Water content, residual palladium or other metals, chromatographic purity, and lot-to-lot analytical consistency may have a greater practical impact on process performance. If a customer has an internal control strategy, the supplier should review those requirements before confirming the product grade.
First, identify whether the material is for reaction screening, route development, pilot production, or routine manufacturing. Screening work may tolerate a broader specification, while a commercial process often requires tighter control of impurities and documentation. The intended use also determines whether a small trial pack or a larger commercial quotation is appropriate.
Next, specify the target assay, acceptable water level, packaging, test methods, and required documents. If the compound will enter a multi-step synthesis, ask whether known impurities could carry forward or interfere with purification. It is also useful to request a recent certificate of analysis and compare its test items with the customer’s internal release criteria.
Price is only one part of the purchasing decision. A reliable evaluation should include minimum order quantity, standard lead time, production capacity, batch continuity, export experience, and communication speed. I recommend asking whether the quoted material is available from stock, scheduled for production, or subject to a new manufacturing campaign.
For an initial order, buyers should compare the delivered cost rather than only the unit price. Packaging, hazardous or chemical transport requirements, customs documentation, insurance, and payment terms can affect the final procurement budget. Lead time should be confirmed in writing, particularly when the product is needed for a fixed research or production schedule.
4-Hydroxyphenylboronic acid should be handled by trained personnel using the precautions specified in the applicable safety data sheet. Avoid unnecessary exposure to moisture, heat, dust, and incompatible reagents, and use suitable personal protective equipment for weighing and transfer. The exact storage recommendation should follow the supplier’s current SDS and product label rather than a generic assumption.
For laboratory operations, I recommend keeping the container tightly closed and minimizing repeated opening. If the process is moisture-sensitive, buyers should discuss inner packaging, desiccant use, nitrogen protection, and container size with the supplier. Any change in appearance, assay, water content, or reaction behavior should be investigated before the material is released for further use.
Another frequent mistake is treating a successful small-scale reaction as proof that every commercial lot will perform identically. Scale, mixing, catalyst loading, base selection, and impurity concentration can change the outcome. A documented incoming-material qualification procedure helps identify differences early and gives both buyer and supplier a clear basis for corrective action.
At Maison Chemical, I approach 4-Hydroxyphenylboronic acid sourcing as a technical and commercial process rather than a simple price transaction. We can discuss the intended application, required quantity, target specification, packaging preference, and destination market before preparing a quotation. This helps align the proposed material with the customer’s actual use.
Our support may include product identification, specification review, batch documentation coordination, packaging discussion, and export-order communication. For customers comparing suppliers, we can clarify available quantities and expected lead times based on the current supply situation. Any custom requirement, such as a particular analytical method or documentation format, should be reviewed in advance so that feasibility is confirmed honestly.
4-Hydroxyphenylboronic acid CAS 71597-85-8 is an aromatic boronic acid with a para-hydroxyl group, a molecular formula of C6H7BO3, and an approximate molecular mass of 137.93 g/mol. Its principal value is as a coupling and synthesis intermediate, especially where both carbon–carbon bond formation and further phenolic functionalization are required. Application results depend on reaction conditions, material quality, moisture control, and the consistency of the supplied batches.
For the next step, define your target assay, quantity, packaging, documentation, and delivery destination, then request a current specification and certificate of analysis from the supplier. If you are evaluating Maison Chemical, send us your required quantity, application stage, and quality criteria for a practical sourcing discussion. We can then help you assess the appropriate supply option and prepare a quotation for 4-Hydroxyphenylboronic acid CAS 71597-85-8.
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