2-(4-Fluorophenyl)-thiophene, identified by CAS No. 58861-48-6, is an aromatic thiophene building block containing a fluorinated phenyl group. Its molecular formula is C10H7FS, and its calculated molecular weight is approximately 178.22 g/mol. I position this compound primarily for research, medicinal chemistry, materials development, and intermediate-sourcing projects where a defined fluorinated heteroaromatic structure is required.
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Because physical specifications such as appearance, purity, melting behavior, and storage conditions can vary by production route and batch, buyers should evaluate the supplier’s current specification sheet, SDS, and CoA rather than relying only on generic catalog descriptions. At Maison Chemical, we support customers by clarifying identity, quality requirements, packaging, documentation, and delivery expectations before an order is confirmed.
This guide is intended for pharmaceutical and specialty chemical companies, medicinal chemistry teams, academic laboratories, materials researchers, and procurement professionals sourcing 2-(4-Fluorophenyl)-thiophene. It is also useful for buyers comparing research-grade material with a more controlled intermediate supply. The goal is to help you understand what can be verified from the molecular structure and what must be confirmed directly with a supplier.
The compound may be relevant when a project needs both a thiophene ring and a para-fluorophenyl substituent in the same molecular framework. However, the correct grade and supply route depend on the intended use, scale, analytical requirements, and downstream processing conditions. I recommend defining these requirements before requesting a quotation.
2-(4-Fluorophenyl)-thiophene consists of a thiophene ring connected through its 2-position to a phenyl ring bearing fluorine at the para, or 4-position. The structure therefore combines a sulfur-containing five-membered aromatic ring with a fluorinated six-membered aromatic ring. This arrangement is important because the two ring systems can be used as a defined structural motif in subsequent synthetic design.
| Parameter | Information |
|---|---|
| Product name | 2-(4-Fluorophenyl)-thiophene |
| CAS number | 58861-48-6 |
| Molecular formula | C10H7FS |
| Approximate molecular weight | 178.22 g/mol |
| Key structural features | One thiophene ring, one fluorophenyl ring, and one fluorine atom |
The molecular weight shown above is calculated from the stated molecular formula and should be used as an identity reference rather than as a substitute for batch testing. A supplier’s analytical documentation should confirm the actual material supplied, including assay and relevant impurity information. If your project requires a particular isomer, make sure the name, structure, and CAS number are aligned across the purchase order, specification, and shipping documents.
Fluorinated aromatic and heteroaromatic fragments are commonly considered in medicinal chemistry because fluorine can influence molecular size, polarity, lipophilicity, and metabolic behavior. That general design rationale does not mean that every fluorinated building block will produce a desired biological effect. Instead, 2-(4-Fluorophenyl)-thiophene can serve as a selectable fragment for synthetic programs in which the thiophene-phenyl arrangement is appropriate.
Researchers may use the compound as a starting material or coupling component in the preparation of more complex screening compounds. The exact reaction pathway depends on the functional groups introduced later and on the customer’s synthetic route. I recommend confirming reactivity and compatibility through laboratory-scale evaluation before planning a larger production campaign.
Thiophene-containing structures are frequently explored in organic materials research because thiophene is an aromatic heterocycle that can participate in conjugated molecular frameworks. A fluorophenyl substituent may be incorporated when researchers are investigating how structural substitution affects electronic, optical, or physical behavior. These effects are system-dependent, so they should be measured for the final designed molecule rather than inferred solely from this intermediate.
Potential uses may include the preparation of research compounds for organic electronics, molecular probes, and specialty functional materials. Whether the compound is suitable depends on the required purity, scale, impurity profile, and downstream purification method. Maison Chemical can discuss these factors before supply so that the material specification matches the actual research objective.
For this compound, the most useful purchasing distinction is usually not a universal “type” classification but the level of quality control required for the application. A small laboratory project may prioritize pack size and rapid availability, while a process-development program may require defined assay, impurity limits, residual solvent control, and batch-to-batch consistency. These requirements should be written into the inquiry rather than assumed.
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Do not request a purity number simply because it appears in another supplier’s listing. A suitable specification should reflect the sensitivity of your reaction and the quality requirements of your final product. For a process-related purchase, I advise buyers to agree on acceptance criteria before production or shipment.
Start by stating whether the material is for screening, route scouting, analytical reference, process development, or commercial intermediate production. This determines the level of documentation and quality control that may be appropriate. It also helps the supplier recommend a practical package size instead of quoting a specification that does not fit the project.
Ask the supplier to confirm the product name, CAS number, formula, molecular weight, and available analytical methods. If your organization uses a specific HPLC, GC, NMR, or other release method, share that requirement during the inquiry. The supplier should then clarify which data are available for the requested lot and which tests would need to be added.
Request pricing by quantity rather than relying on a single sample-pack price. A practical inquiry may compare a 10 g laboratory quantity, a 100 g development quantity, and a larger project requirement, but the appropriate options depend on actual availability. Ask separately about MOQ, production lead time, sample policy, packaging, payment terms, and shipping documentation.
For repeated purchases, discuss whether the same specification can be maintained across future batches. You should also ask how change control, batch records, and retained samples are handled when these controls are relevant to your quality system. No supplier should be selected solely on unit price if inconsistent material could delay synthesis or create requalification work.
One common mistake is treating the CAS number as proof of complete quality suitability. The CAS number helps identify the substance, but it does not establish a particular assay, impurity profile, production method, or regulatory status. Another mistake is failing to distinguish a research quantity from a scale-up requirement, which can lead to different packaging, testing, and lead-time expectations.
Buyers should also avoid assuming that physical data from an unrelated listing apply to every batch. If melting point, color, concentration, or a specific impurity limit matters to your process, request current lot-specific evidence. Finally, confirm whether the product is being purchased as a standalone chemical intermediate and whether any additional declarations are needed for your import, handling, or internal approval procedures.
At Maison Chemical, I approach 2-(4-Fluorophenyl)-thiophene sourcing as a technical and commercial evaluation rather than a simple catalog transaction. We can review your target quantity, intended application, required documentation, packaging preferences, and delivery destination before preparing a quotation. When the available information is not sufficient to support a firm specification, we state that limitation clearly and identify which details require confirmation.
Our support can be useful for laboratory procurement, pharmaceutical intermediate development, and specialty chemical projects that need a responsive manufacturing and export partner. Depending on the project, we can discuss sample arrangements, batch documentation, quality requirements, and potential custom supply planning. Any final specification, lead time, and price should be confirmed against the current production and logistics status.
2-(4-Fluorophenyl)-thiophene CAS 58861-48-6 can be a useful defined building block when your synthesis or materials program requires a thiophene ring linked to a para-fluorophenyl group. Its basic identity is clear, but application suitability depends on the downstream route and the quality criteria for your project. I recommend confirming the structure, required assay, impurity limits, documentation, quantity, and delivery schedule before placing an order.
To request a quotation from Maison Chemical, send the CAS number, target quantity, intended use, required specification, destination, and preferred delivery timeframe. We will use that information to assess the appropriate supply option and clarify any points that cannot be verified from standard product information. This approach helps you obtain a technically suitable and commercially practical solution for your 2-(4-Fluorophenyl)-thiophene requirement.
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