POMEGRANATE: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

29 Jun.,2023

 

Abidov, M., Jimenez Del, Rio M., Ramazanov, A., Kalyuzhin, O., and Chkhikvishvili, I. Efficiency of pharmacologically-active antioxidant phytomedicine Radical Fruits in treatment hypercholesteremia at men. Georgian.Med News 2006;(140):78-83. View abstract.

Abidov, M., Ramazanov, Z., Seifulla, R., and Grachev, S. The effects of Xanthigen in the weight management of obese premenopausal women with non-alcoholic fatty liver disease and normal liver fat. Diabetes Obes.Metab 2010;12(1):72-81. View abstract.

Adams, L. S., Seeram, N. P., Aggarwal, B. B., Takada, Y., Sand, D., and Heber, D. Pomegranate juice, total pomegranate ellagitannins, and punicalagin suppress inflammatory cell signaling in colon cancer cells. J Agric Food Chem 2-8-2006;54(3):980-985. View abstract.

Adams, L. S., Zhang, Y., Seeram, N. P., Heber, D., and Chen, S. Pomegranate ellagitannin-derived compounds exhibit antiproliferative and antiaromatase activity in breast cancer cells in vitro. Cancer Prev.Res.(Phila) 2010;3(1):108-113. View abstract.

Adhikari, A., Devkota, H. P., Takano, A., Masuda, K., Nakane, T., Basnet, P., and Skalko-Basnet, N. Screening of Nepalese crude drugs traditionally used to treat hyperpigmentation: in vitro tyrosinase inhibition. Int.J Cosmet.Sci 2008;30(5):353-360. View abstract.

Adiga, S. Trivedi P. Ravichandra V. Deb D. and Mehta F. Effect of Punica granatum peel extract on learning and memory in rats. Asian Pacific Journal of Tropical Medicine 2010;3(9):687-690.

Afaq, F., Khan, N., Syed, D. N., and Mukhtar, H. Oral feeding of pomegranate fruit extract inhibits early biomarkers of UVB radiation-induced carcinogenesis in SKH-1 hairless mouse epidermis. Photochem.Photobiol. 2010;86(6):1318-1326. View abstract.

Afaq, F., Malik, A., Syed, D., Maes, D., Matsui, M. S., and Mukhtar, H. Pomegranate fruit extract modulates UV-B-mediated phosphorylation of mitogen-activated protein kinases and activation of nuclear factor kappa B in normal human epidermal keratinocytes paragraph sign. Photochem Photobiol 2005;81(1):38-45. View abstract.

Afaq, F., Saleem, M., Krueger, C. G., Reed, J. D., and Mukhtar, H. Anthocyanin- and hydrolyzable tannin-rich pomegranate fruit extract modulates MAPK and NF-kappaB pathways and inhibits skin tumorigenesis in CD-1 mice. Int J Cancer 1-20-2005;113(3):423-433. View abstract.

Afaq, F., Zaid, M. A., Khan, N., Dreher, M., and Mukhtar, H. Protective effect of pomegranate-derived products on UVB-mediated damage in human reconstituted skin. Exp.Dermatol. 2009;18(6):553-561. View abstract.

Ahshawat, M. S., Saraf, S., and Saraf, S. Preparation and characterization of herbal creams for improvement of skin viscoelastic properties. Int.J Cosmet.Sci. 2008;30(3):183-193. View abstract.

Al-Mustafa, A. H. and Al-Thunibat, O. Y. Antioxidant activity of some Jordanian medicinal plants used traditionally for treatment of diabetes. Pak.J.Biol.Sci. 2-1-2008;11(3):351-358. View abstract.

Al-Zoreky, N. S. Antimicrobial activity of pomegranate (Punica granatum L.) fruit peels. Int.J.Food Microbiol. 9-15-2009;134(3):244-248. View abstract.

Alam, M. S., Alam, M. A., Ahmad, S., Najmi, A. K., Asif, M., and Jahangir, T. Protective effects of Punica granatum in experimentally-induced gastric ulcers. Toxicol.Mech.Methods 2010;20(9):572-578. View abstract.

Albrecht, M., Schneider, O., and Schmidt, A. Redox active donor-substituted punicin derivatives. Org.Biomol.Chem. 4-7-2009;7(7):1445-1453. View abstract.

Alighourchi, H. Barzegar M. and Abbasi S. Effect of gamma irradiation on the stability of anthocyanins and shelf-life of various pomegranate juices. Food Chemistry 2008;110(4):1036-1040.

Bachoual, R., Talmoudi, W., Boussetta, T., Braut, F., and El-Benna, J. An aqueous pomegranate peel extract inhibits neutrophil myeloperoxidase in vitro and attenuates lung inflammation in mice. Food Chem.Toxicol. 2011;49(6):1224-1228. View abstract.

Bae, J. Y., Choi, J. S., Kang, S. W., Lee, Y. J., Park, J., and Kang, Y. H. Dietary compound ellagic acid alleviates skin wrinkle and inflammation induced by UV-B irradiation. Exp.Dermatol. 2010;19(8):e182-e190. View abstract.

Bagri, P., Ali, M., Aeri, V., Bhowmik, M., and Sultana, S. Antidiabetic effect of Punica granatum flowers: effect on hyperlipidemia, pancreatic cells lipid peroxidation and antioxidant enzymes in experimental diabetes. Food Chem.Toxicol. 2009;47(1):50-54. View abstract.

Bagri, P., Ali, M., Sultana, S., and Aeri, V. New sterol esters from the flowers of Punica granatum Linn. J.Asian Nat.Prod.Res. 2009;11(8):710-715. View abstract.

Balwani, S., Nandi, D., Jaisankar, P., and Ghosh, B. 2-Methyl-pyran-4-one-3-O-beta-D-glucopyranoside isolated from leaves of Punica granatum inhibits the TNFalpha-induced cell adhesion molecules expression by blocking nuclear transcription factor-kappaB (NF-kappaB). Biochimie 2011;93(5):921-930. View abstract.

Belal, S. K. M. Abdel-Rahman A. H. Mohamed D. S. Osman H. E. H. and Hassan N. A. Protective effect of pomegranate fruit juice against Aeromonas hydrophila-induced intestinal histopathological changes in mice. World Applied Sciences Journal 2009;7(2):245-254.

Bell, C. and Hawthorne, S. Ellagic acid, pomegranate and prostate cancer -- a mini review. J.Pharm.Pharmacol. 2008;60(2):139-144. View abstract.

Beltz, J. McNeil C. Fisher M. Shaw P. Breece L. Sellers T. andBrown K. Investigation of the antihyperalgesic effects of the pomegranate extract ellagic acid. AANA Journal 2008;76(5):365-366.

Ben-Simhon, Z., Judeinstein, S., Nadler-Hassar, T., Trainin, T., Bar-Ya'akov, I., Borochov-Neori, H., and Holland, D. A pomegranate (Punica granatum L.) WD40-repeat gene is a functional homologue of Arabidopsis TTG1 and is involved in the regulation of anthocyanin biosynthesis during pomegranate fruit development. Planta 2011;234(5):865-881. View abstract.

Benherlal, P. S. and Arumughan, C. Studies on modulation of DNA integrity in Fenton's system by phytochemicals. Mutat.Res. 12-15-2008;648(1-2):1-8. View abstract.

Benzer, F. Kandemir F. M. Yildirim N. C. and Ozan S. T. Effect of pomegranate seed extract on free radical damage and antioxidant activity under cisplatin-induced oxidative stress conditions in rabbit testes. Asian Journal of Chemistry 2011;23(7):3131-3234.

Bhadbhade, S. J., Acharya, A. B., Rodrigues, S. V., and Thakur, S. L. The antiplaque efficacy of pomegranate mouthrinse. Quintessence.Int. 2011;42(1):29-36. View abstract.

Bialonska, D., Kasimsetty, S. G., Khan, S. I., and Ferreira, D. Urolithins, intestinal microbial metabolites of Pomegranate ellagitannins, exhibit potent antioxidant activity in a cell-based assay. J.Agric.Food Chem. 11-11-2009;57(21):10181-10186. View abstract.

Bialonska, D., Kasimsetty, S. G., Schrader, K. K., and Ferreira, D. The effect of pomegranate (Punica granatum L.) byproducts and ellagitannins on the growth of human gut bacteria. J.Agric.Food Chem. 9-23-2009;57(18):8344-8349. View abstract.

Bishayee, A., Bhatia, D., Thoppil, R. J., Darvesh, A. S., Nevo, E., and Lansky, E. P. Pomegranate-mediated chemoprevention of experimental hepatocarcinogenesis involves Nrf2-regulated antioxidant mechanisms. Carcinogenesis 2011;32(6):888-896. View abstract.

Borochov-Neori, H., Judeinstein, S., Harari, M., Bar-Ya'akov, I., Patil, B. S., Lurie, S., and Holland, D. Climate effects on anthocyanin accumulation and composition in the pomegranate (Punica granatum L.) fruit arils. J.Agric.Food Chem. 5-25-2011;59(10):5325-5334. View abstract.

Bouroshaki, M. T., Sadeghnia, H. R., Banihasan, M., and Yavari, S. Protective effect of pomegranate seed oil on hexachlorobutadiene-induced nephrotoxicity in rat kidneys. Ren Fail. 2010;32(5):612-617. View abstract.

Boussetta, T., Raad, H., Letteron, P., Gougerot-Pocidalo, M. A., Marie, J. C., Driss, F., and El-Benna, J. Punicic acid a conjugated linolenic acid inhibits TNFalpha-induced neutrophil hyperactivation and protects from experimental colon inflammation in rats. PLoS.One. 2009;4(7):e6458. View abstract.

Calin-Sanchez, A., Martinez, J. J., Vazquez-Araujo, L., Burlo, F., Melgarejo, P., and Carbonell-Barrachina, A. A. Volatile composition and sensory quality of Spanish pomegranates (Punica granatum L.). J.Sci.Food Agric. 2011;91(3):586-592. View abstract.

Carpenter, L. A. Conway C. J. and Pipkin F. B. Pomegranates (Punica granatum) and their effect on blood pressure: a randomised double-blind placebo-controlled trial. Proceedings of the Nutrition Society 2010;69(1):95.

Cayir, K., Karadeniz, A., Simsek, N., Yildirim, S., Karakus, E., Kara, A., Akkoyun, H. T., and Sengul, E. Pomegranate seed extract attenuates chemotherapy-induced acute nephrotoxicity and hepatotoxicity in rats. J.Med.Food 2011;14(10):1254-1262. View abstract.

Celik, I., Temur, A., and Isik, I. Hepatoprotective role and antioxidant capacity of pomegranate (Punica granatum) flowers infusion against trichloroacetic acid-exposed in rats. Food Chem.Toxicol. 2009;47(1):145-149. View abstract.

Cerda, B., Espin, J. C., Parra, S., Martinez, P., and Tomas-Barberan, F. A. The potent in vitro antioxidant ellagitannins from pomegranate juice are metabolised into bioavailable but poor antioxidant hydroxy-6H-dibenzopyran-6-one derivatives by the colonic microflora of healthy humans. Eur.J.Nutr. 2004;43(4):205-220. View abstract.

Choi, J. G., Kang, O. H., Lee, Y. S., Chae, H. S., Oh, Y. C., Brice, O. O., Kim, M. S., Sohn, D. H., Kim, H. S., Park, H., Shin, D. W., Rho, J. R., and Kwon, D. Y. In Vitro and In Vivo Antibacterial Activity of Punica granatum Peel Ethanol Extract against Salmonella. Evid.Based.Complement Alternat.Med. 2011;2011:690518. View abstract.

Choi, S. J., Lee, J. H., Heo, H. J., Cho, H. Y., Kim, H. K., Kim, C. J., Kim, M. O., Suh, S. H., and Shin, D. H. Punica granatum protects against oxidative stress in PC12 cells and oxidative stress-induced Alzheimer's symptoms in mice. J.Med.Food 2011;14(7-8):695-701. View abstract.

Chong, M. F., Macdonald, R., and Lovegrove, J. A. Fruit polyphenols and CVD risk: a review of human intervention studies. Br.J.Nutr. 2010;104 Suppl 3:S28-S39. View abstract.

Cuccioloni, M., Mozzicafreddo, M., Sparapani, L., Spina, M., Eleuteri, A. M., Fioretti, E., and Angeletti, M. Pomegranate fruit components modulate human thrombin. Fitoterapia 2009;80(5):301-305. View abstract.

Dahham, S. S. Ali M. N. Tabassum H. and Khan M. Studies on antibacterial and antifungal activity of pomegranate (Punica granatum L.). American-Eurasian Journal of Agricultural and Environmental Science 2010;9(3):273-281.

Dai, Z., Nair, V., Khan, M., and Ciolino, H. P. Pomegranate extract inhibits the proliferation and viability of MMTV-Wnt-1 mouse mammary cancer stem cells in vitro. Oncol.Rep. 2010;24(4):1087-1091. View abstract.

Darji, V. C. Bariya A. H. Deshpande S. S. and Patel D. A. Effect of Punica granatum fruits in inflammatory bowel disease. Journal of Pharmacy Research 2010;3(12):2850-2852.

Das, A. K., Mandal, S. C., Banerjee, S. K., Sinha, S., Das, J., Saha, B. P., and Pal, M. Studies on antidiarrhoeal activity of Punica granatum seed extract in rats. J Ethnopharmacol. 12-15-1999;68(1-3):205-208. View abstract.

de Nigris, F., Balestrieri, M. L., Williams-Ignarro, S., D'Armiento, F. P., Fiorito, C., Ignarro, L. J., and Napoli, C. The influence of pomegranate fruit extract in comparison to regular pomegranate juice and seed oil on nitric oxide and arterial function in obese Zucker rats. Nitric.Oxide. 2007;17(1):50-54. View abstract.

de Nigris, F., Williams-Ignarro, S., Botti, C., Sica, V., Ignarro, L. J., and Napoli, C. Pomegranate juice reduces oxidized low-density lipoprotein downregulation of endothelial nitric oxide synthase in human coronary endothelial cells. Nitric.Oxide. 2006;15(3):259-263. View abstract.

de Nigris, F., Williams-Ignarro, S., Sica, V., Lerman, L. O., D'Armiento, F. P., Byrns, R. E., Casamassimi, A., Carpentiero, D., Schiano, C., Sumi, D., Fiorito, C., Ignarro, L. J., and Napoli, C. Effects of a pomegranate fruit extract rich in punicalagin on oxidation-sensitive genes and eNOS activity at sites of perturbed shear stress and atherogenesis. Cardiovasc.Res 1-15-2007;73(2):414-423. View abstract.

De, M., Krishna, De A., and Banerjee, A. B. Antimicrobial screening of some Indian spices. Phytother.Res. 1999;13(7):616-618. View abstract.

Dell'Agli, M., Galli, G. V., Bulgari, M., Basilico, N., Romeo, S., Bhattacharya, D., Taramelli, D., and Bosisio, E. Ellagitannins of the fruit rind of pomegranate (Punica granatum) antagonize in vitro the host inflammatory response mechanisms involved in the onset of malaria. Malar.J. 2010;9:208. View abstract.

Dell'Agli, M., Galli, G. V., Corbett, Y., Taramelli, D., Lucantoni, L., Habluetzel, A., Maschi, O., Caruso, D., Giavarini, F., Romeo, S., Bhattacharya, D., and Bosisio, E. Antiplasmodial activity of Punica granatum L. fruit rind. J.Ethnopharmacol. 9-7-2009;125(2):279-285. View abstract.

Devatkal, S. K., Narsaiah, K., and Borah, A. Anti-oxidant effect of extracts of kinnow rind, pomegranate rind and seed powders in cooked goat meat patties. Meat.Sci. 2010;85(1):155-159. View abstract.

Duman, A. D., Ozgen, M., Dayisoylu, K. S., Erbil, N., and Durgac, C. Antimicrobial activity of six pomegranate (Punica granatum L.) varieties and their relation to some of their pomological and phytonutrient characteristics. Molecules. 2009;14(5):1808-1817. View abstract.

El, Kar C., Ferchichi, A., Attia, F., and Bouajila, J. Pomegranate (Punica granatum) juices: chemical composition, micronutrient cations, and antioxidant capacity. J.Food Sci. 2011;76(6):C795-C800. View abstract.

El-Sherbini, G. M., Ibrahim, K. M., El Sherbiny, E. T., Abdel-Hady, N. M., and Morsy, T. A. Efficacy of Punica granatum extract on in-vitro and in-vivo control of Trichomonas vaginalis. J.Egypt.Soc.Parasitol. 2010;40(1):229-244. View abstract.

Elfalleh, W. Tlili N. Nasri N. Yahia Y. Hannachi H. Chaira N. Ying M. and Ferchichi A. Antioxidant Capacities of Phenolic Compounds and Tocopherols from Tunisian Pomegranate ( Punica granatum) Fruits. Journal of Food Science 2011;76(5):c707-c713.

Elfalleh, W., Nasri, N., Marzougui, N., Thabti, I., M'rabet, A., Yahya, Y., Lachiheb, B., Guasmi, F., and Ferchichi, A. Physico-chemical properties and DPPH-ABTS scavenging activity of some local pomegranate (Punica granatum) ecotypes. Int.J.Food Sci.Nutr. 2009;60 Suppl 2:197-210. View abstract.

Elfalleh, W., Ying, M., Nasri, N., Sheng-Hua, H., Guasmi, F., and Ferchichi, A. Fatty acids from Tunisian and Chinese pomegranate (Punica granatum L.) seeds. Int.J.Food Sci.Nutr. 2011;62(3):200-206. View abstract.

Endo, E. H., Cortez, D. A., Ueda-Nakamura, T., Nakamura, C. V., and Dias Filho, B. P. Potent antifungal activity of extracts and pure compound isolated from pomegranate peels and synergism with fluconazole against Candida albicans. Res.Microbiol. 2010;161(7):534-540. View abstract.

Esmaillzadeh, A., Tahbaz, F., Gaieni, I., Alavi-Majd, H., and Azadbakht, L. Cholesterol-lowering effect of concentrated pomegranate juice consumption in type II diabetic patients with hyperlipidemia. Int J Vitam.Nutr Res 2006;76(3):147-151. View abstract.

Fahmy, Z. H. El-Shennawy A. M. El-Komy W. Ali E. and Hamid S. S. A. Potential antiparasitic activity of pomegranate extracts against shistosomules and mature worms of Schistosoma mansoni: in vitro and in vivo study. Australian Journal of Basic and Applied Sciences 2009;3(4):4634-4643.

Faria, A., Monteiro, R., Azevedo, I., and Calhau, C. Comment on safety and antioxidant activity of a pomegranate ellagitannin-enriched polyphenol dietary supplement in overweight individuals with increased waist size. J.Agric.Food Chem. 12-24-2008;56(24):12143-12144. View abstract.

Fazeli, M. R., Bahmani, S., Jamalifar, H., and Samadi, N. Effect of probiotication on antioxidant and antibacterial activities of pomegranate juices from sour and sweet cultivars. Nat.Prod.Res. 2011;25(3):288-297. View abstract.

Fazio, M. L. S. Gonçalves T. M. V. and Hoffmann F. L. Determination of antibacterial activity of pomegranate (Punicea granatum L.). / Determinação da atividade antibacteriana de romã (Punica granatum L.). Higiene Alimentar 2009;23(168/169):54-56.

Forest, C. P., Padma-Nathan, H., and Liker, H. R. Efficacy and safety of pomegranate juice on improvement of erectile dysfunction in male patients with mild to moderate erectile dysfunction: a randomized, placebo-controlled, double-blind, crossover study. Int J Impot.Res 2007;19(6):564-567. View abstract.

Fuhrman, B., Volkova, N., and Aviram, M. Pomegranate juice inhibits oxidized LDL uptake and cholesterol biosynthesis in macrophages. J Nutr Biochem 2005;16(9):570-576. View abstract.

Fuhrman, B., Volkova, N., and Aviram, M. Pomegranate juice polyphenols increase recombinant paraoxonase-1 binding to high-density lipoprotein: studies in vitro and in diabetic patients. Nutrition 2010;26(4):359-366. View abstract.

Gaig, P., Botey, J., Gutierrez, V., Pena, M., Eseverri, J. L., and Marin, A. Allergy to pomegranate (Punica granatum). J.Investig.Allergol.Clin.Immunol. 1992;2(4):216-218. View abstract.

Garcia, M., Monzote, L., Montalvo, A. M., and Scull, R. Screening of medicinal plants against Leishmania amazonensis. Pharm.Biol. 2010;48(9):1053-1058. View abstract.

Gasmi, J. and Sanderson, J. T. Growth Inhibitory, Antiandrogenic, and Pro-apoptotic Effects of Punicic Acid in LNCaP Human Prostate Cancer Cells. J.Agric.Food Chem. 11-10-2010; View abstract.

Gillis, T. Johnson G. King B. Wilson J. andDominguez J. Investigation of ellagic acid, a pomegranate fruit extract, as a non-anti-inflammatory pathway analgesic. AANA Journal 2008;76(5):373-374.

Gonzalez-Sarrias, A., Larrosa, M., Tomas-Barberan, F. A., Dolara, P., and Espin, J. C. NF-kappaB-dependent anti-inflammatory activity of urolithins, gut microbiota ellagic acid-derived metabolites, in human colonic fibroblasts. Br.J.Nutr. 2010;104(4):503-512. View abstract.

Gould, S. W., Fielder, M. D., Kelly, A. F., and Naughton, D. P. Anti-microbial activities of pomegranate rind extracts: enhancement by cupric sulphate against clinical isolates of S. aureus, MRSA and PVL positive CA-MSSA. BMC.Complement Altern.Med. 2009;9:23. View abstract.

Gould, S. W., Fielder, M. D., Kelly, A. F., El, Sankary W., and Naughton, D. P. Antimicrobial pomegranate rind extracts: enhancement by Cu(II) and vitamin C combinations against clinical isolates of Pseudomonas aeruginosa. Br.J.Biomed.Sci. 2009;66(3):129-132. View abstract.

Gozlekci, S., Saracoglu, O., Onursal, E., and Ozgen, M. Total phenolic distribution of juice, peel, and seed extracts of four pomegranate cultivars. Pharmacogn.Mag. 2011;7(26):161-164. View abstract.

Gracious, Ross R., Selvasubramanian, S., and Jayasundar, S. Immunomodulatory activity of Punica granatum in rabbits--a preliminary study. J Ethnopharmacol. 2001;78(1):85-87. View abstract.

Grossmann, M. E., Mizuno, N. K., Schuster, T., and Cleary, M. P. Punicic acid is an omega-5 fatty acid capable of inhibiting breast cancer proliferation. Int.J.Oncol. 2010;36(2):421-426. View abstract.

Guo, C., Wei, J., Yang, J., Xu, J., Pang, W., and Jiang, Y. Pomegranate juice is potentially better than apple juice in improving antioxidant function in elderly subjects. Nutr.Res. 2008;28(2):72-77. View abstract.

Guo, G., Wang, H. X., and Ng, T. B. Pomegranin, an antifungal peptide from pomegranate peels. Protein Pept.Lett. 2009;16(1):82-85. View abstract.

Haber, S. L., Joy, J. K., and Largent, R. Antioxidant and antiatherogenic effects of pomegranate. Am.J.Health Syst.Pharm. 7-15-2011;68(14):1302-1305. View abstract.

Hadipour-Jahromy, M. and Mozaffari-Kermani, R. Chondroprotective effects of pomegranate juice on monoiodoacetate-induced osteoarthritis of the knee joint of mice. Phytother.Res. 2010;24(2):182-185. View abstract.

Hajimahmoodi, M. Oveisi M. R. Sadeghi N. Jannat B. and Nateghi M. Antioxidant capacity of plasma after pomegranate intake in human volunteers. 2009;47(2):125-132. Acta Medica Iranica 2009;47(2):125-132.

Hajimahmoodi, M., Oveisi, M. R., Sadeghi, N., Jannat, B., Hadjibabaie, M., Farahani, E., Akrami, M. R., and Namdar, R. Antioxidant properties of peel and pulp hydro extract in ten Persian pomegranate cultivars. Pak.J.Biol.Sci. 6-15-2008;11(12):1600-1604. View abstract.

Hajimahmoodi, M., Shams-Ardakani, M., Saniee, P., Siavoshi, F., Mehrabani, M., Hosseinzadeh, H., Foroumadi, P., Safavi, M., Khanavi, M., Akbarzadeh, T., Shafiee, A., and Foroumadi, A. In vitro antibacterial activity of some Iranian medicinal plant extracts against Helicobacter pylori. Nat.Prod.Res. 2011;25(11):1059-1066. View abstract.

Hanif, S., Shamim, U., Ullah, M. F., Azmi, A. S., Bhat, S. H., and Hadi, S. M. The anthocyanidin delphinidin mobilizes endogenous copper ions from human lymphocytes leading to oxidative degradation of cellular DNA. Toxicology 7-10-2008;249(1):19-25. View abstract.

Harikrishnan, R., Heo, J., Balasundaram, C., Kim, M. C., Kim, J. S., Han, Y. J., and Heo, M. S. Effect of Punica granatum solvent extracts on immune system and disease resistance in Paralichthys olivaceus against lymphocystis disease virus (LDV). Fish.Shellfish.Immunol. 2010;29(4):668-673. View abstract.

Harikrishnan, R., Heo, J., Balasundaram, C., Kim, M. C., Kim, J. S., Han, Y. J., and Heo, M. S. Effect of traditional Korean medicinal (TKM) triherbal extract on the innate immune system and disease resistance in Paralichthys olivaceus against Uronema marinum. Vet.Parasitol. 5-28-2010;170(1-2):1-7. View abstract.

Hartman, R. E., Shah, A., Fagan, A. M., Schwetye, K. E., Parsadanian, M., Schulman, R. N., Finn, M. B., and Holtzman, D. M. Pomegranate juice decreases amyloid load and improves behavior in a mouse model of Alzheimer's disease. Neurobiol.Dis 2006;24(3):506-515. View abstract.

Hashemi, M., Kelishadi, R., Hashemipour, M., Zakerameli, A., Khavarian, N., Ghatrehsamani, S., and Poursafa, P. Acute and long-term effects of grape and pomegranate juice consumption on vascular reactivity in paediatric metabolic syndrome. Cardiol Young. 2010;20(1):73-77. View abstract.

Hassanpour, Fard M., Ghule, A. E., Bodhankar, S. L., and Dikshit, M. Cardioprotective effect of whole fruit extract of pomegranate on doxorubicin-induced toxicity in rat. Pharm.Biol. 2011;49(4):377-382. View abstract.

Hayouni, E. A., Miled, K., Boubaker, S., Bellasfar, Z., Abedrabba, M., Iwaski, H., Oku, H., Matsui, T., Limam, F., and Hamdi, M. Hydroalcoholic extract based-ointment from Punica granatum L. peels with enhanced in vivo healing potential on dermal wounds. Phytomedicine. 8-15-2011;18(11):976-984. View abstract.

Heber, D. Multitargeted therapy of cancer by ellagitannins. Cancer Lett. 10-8-2008;269(2):262-268. View abstract.

Hemmati, A. A. Arzi A. Sistani N. K. and Mikaili P. The hydro-alcoholic extract of pomegranate seed has anti-inflammatory effects on formalin-induced inflammation in rat hind paw. Research Journal of Biological Sciences 2010;5(8):561-564.

Hepaksoy, S. Erogul D. Sen F. and Aksoy U. Antioxidant activity and total phenolic content of some Turkish pomegranate varieties. Acta Horticulturae 2009;818:241-248.

Hofling, J. F., Anibal, P. C., Obando-Pereda, G. A., Peixoto, I. A., Furletti, V. F., Foglio, M. A., and Goncalves, R. B. Antimicrobial potential of some plant extracts against Candida species. Braz.J.Biol. 2010;70(4):1065-1068. View abstract.

Hong, M. Y., Seeram, N. P., and Heber, D. Pomegranate polyphenols down-regulate expression of androgen-synthesizing genes in human prostate cancer cells overexpressing the androgen receptor. J.Nutr.Biochem. 2008;19(12):848-855. View abstract.

Hontecillas, R., O'Shea, M., Einerhand, A., Diguardo, M., and Bassaganya-Riera, J. Activation of PPAR gamma and alpha by punicic acid ameliorates glucose tolerance and suppresses obesity-related inflammation. J.Am.Coll.Nutr. 2009;28(2):184-195. View abstract.

Hossin, F. L. A. Effect of pomegranate (Punica granatum) peels and it's extract on obese hypercholesterolemic rats. Pakistan Journal of Nutrition 2009;8(8):1251-1257.

Hunt, K. J., Hung, S. K., and Ernst, E. Botanical extracts as anti-aging preparations for the skin: a systematic review. Drugs Aging 12-1-2010;27(12):973-985. View abstract.

Ibrahium, M. I. Efficiency of pomegranate peel extract as antimicrobial, antioxidant and protective agents. World Journal of Agricultural Sciences 2010;6(4):338-344.

Ignarro, L. J., Byrns, R. E., Sumi, D., de Nigris, F., and Napoli, C. Pomegranate juice protects nitric oxide against oxidative destruction and enhances the biological actions of nitric oxide. Nitric.Oxide. 2006;15(2):93-102. View abstract.

Ilbey, Y. O., Ozbek, E., Simsek, A., Cekmen, M., Somay, A., and Tasci, A. I. Effects of pomegranate juice on hyperoxaluria-induced oxidative stress in the rat kidneys. Ren Fail. 2009;31(6):522-531. View abstract.

Iqbal, B. Saeed M. K. Khalid B. Liaquat L. and Ahmad I. Nutritional Value and Antioxidant Activity of Various Extracts and Fractions of <it>Punka granatum</it> (Pomegranate) Peel. Pakistan Journal of Scientific and Industrial Research 2010;53:330-333.

Jadeja, R. N., Thounaojam, M. C., Patel, D. K., Devkar, R. V., and Ramachandran, A. V. Pomegranate (Punica granatum L.) juice supplementation attenuates isoproterenol-induced cardiac necrosis in rats. Cardiovasc.Toxicol. 2010;10(3):174-180. View abstract.

Jafri, M. A., Aslam, M., Javed, K., and Singh, S. Effect of Punica granatum Linn. (flowers) on blood glucose level in normal and alloxan-induced diabetic rats. J Ethnopharmacol. 2000;70(3):309-314. View abstract.

Jardini, F. A. Lima A. de Mendonça R. M. Z. Pinto R. J. Mancini D. A. P. and Mancini Filho J. Phenolic compounds from pulp and seeds of pomegranate (Punica granatum, L.): antioxidant activity and protection of MDCK cells. / Compostos fenólicos da polpa e sementes de romã (Punica granatum, L.): atividade antioxidante e protetora em células MDCK. Alimentos e Nutrição 2010;21(4):509-517.

Jing, X. HuanRong D. and Gong Y. Effect of pomegranate juice and apple juice on free radical metabolism in liver, heart and brain of aged rats. Chinese Journal of Prevention and Control of Chronic Diseases 2011;19(2):185-187.

Jurenka, J. S. Therapeutic applications of pomegranate (Punica granatum L.): a review. Altern.Med.Rev. 2008;13(2):128-144. View abstract.

Kahya, V., Meric, A., Yazici, M., Yuksel, M., Midi, A., and Gedikli, O. Antioxidant effect of pomegranate extract in reducing acute inflammation due to myringotomy. J.Laryngol.Otol. 2011;125(4):370-375. View abstract.

Kasai, K., Yoshimura, M., Koga, T., Arii, M., and Kawasaki, S. Effects of oral administration of ellagic acid-rich pomegranate extract on ultraviolet-induced pigmentation in the human skin. J Nutr Sci Vitaminol.(Tokyo) 2006;52(5):383-388. View abstract.

Kasimsetty, S. G., Bialonska, D., Reddy, M. K., Ma, G., Khan, S. I., and Ferreira, D. Colon cancer chemopreventive activities of pomegranate ellagitannins and urolithins. J.Agric.Food Chem. 2-24-2010;58(4):2180-2187. View abstract.

Kasimsetty, S. G., Bialonska, D., Reddy, M. K., Thornton, C., Willett, K. L., and Ferreira, D. Effects of pomegranate chemical constituents/intestinal microbial metabolites on CYP1B1 in 22Rv1 prostate cancer cells. J.Agric.Food Chem. 11-25-2009;57(22):10636-10644. View abstract.

Kawaii, S. and Lansky, E. P. Differentiation-promoting activity of pomegranate (Punica granatum) fruit extracts in HL-60 human promyelocytic leukemia cells. J.Med.Food 2004;7(1):13-18. View abstract.

Kelebek, H. and Canbas A. Organic acid, sugar and phenolic compounds and antioxidant capacity of Hicaz pomegranate juice. / Hicaz nar srasnn organik asit seker ve fenol bilesikleri icerigI ve antioksidan kapasitesi. GIDA - Journal of Food 2010;35(6):439-444.

Kelishadi, R., Gidding, S. S., Hashemi, M., Hashemipour, M., Zakerameli, A., and Poursafa, P. Acute and long term effects of grape and pomegranate juice consumption on endothelial dysfunction in pediatric metabolic syndrome. J.Res.Med.Sci. 2011;16(3):245-253. View abstract.

Khalife, S. and Zafarullah, M. Molecular targets of natural health products in arthritis. Arthritis Res.Ther. 2011;13(1):102. View abstract.

Khan, G. N., Gorin, M. A., Rosenthal, D., Pan, Q., Bao, L. W., Wu, Z. F., Newman, R. A., Pawlus, A. D., Yang, P., Lansky, E. P., and Merajver, S. D. Pomegranate fruit extract impairs invasion and motility in human breast cancer. Integr.Cancer Ther. 2009;8(3):242-253. View abstract.

Khateeb, J., Gantman, A., Kreitenberg, A. J., Aviram, M., and Fuhrman, B. Paraoxonase 1 (PON1) expression in hepatocytes is upregulated by pomegranate polyphenols: a role for PPAR-gamma pathway. Atherosclerosis 2010;208(1):119-125. View abstract.

Khennouf, S., Gharzouli, K., Amira, S., and Gharzouli, A. Effects of Quercus ilex L. and Punica granatum L. polyphenols against ethanol-induced gastric damage in rats. Pharmazie 1999;54(1):75-76. View abstract.

Kiefer, D. In the news, Pomegranate improves sperm quality. Life Extension 2008;14(5):18.

Kim, Y. H. and Choi, E. M. Stimulation of osteoblastic differentiation and inhibition of interleukin-6 and nitric oxide in MC3T3-E1 cells by pomegranate ethanol extract. Phytother.Res. 2009;23(5):737-739. View abstract.

Kishore, R. K., Sudhakar, D., and Parthasarathy, P. R. Embryo protective effect of pomegranate (Punica granatum L.) fruit extract in adriamycin-induced oxidative stress. Indian J.Biochem.Biophys. 2009;46(1):106-111. View abstract.

Koh, K. H. and Tham, F. Y. Screening of traditional Chinese medicinal plants for quorum-sensing inhibitors activity. J.Microbiol.Immunol.Infect. 2011;44(2):144-148. View abstract.

Koyama, S., Cobb, L. J., Mehta, H. H., Seeram, N. P., Heber, D., Pantuck, A. J., and Cohen, P. Pomegranate extract induces apoptosis in human prostate cancer cells by modulation of the IGF-IGFBP axis. Growth Horm.IGF.Res. 2010;20(1):55-62. View abstract.

Kuang, N. Z., He, Y., Xu, Z. Z., Bao, L., He, R. R., and Kurihara, H. [Effect of pomegranate peel extracts on experimental prostatitis rats]. Zhong.Yao Cai. 2009;32(2):235-239. View abstract.

Kumar, S., Maheshwari, K. K., and Singh, V. Central nervous system activity of acute administration of ethanol extract of Punica granatum L. seeds in mice. Indian J.Exp.Biol. 2008;46(12):811-816. View abstract.

Kumar-Roine, S., Matsui, M., Reybier, K., Darius, H. T., Chinain, M., Pauillac, S., and Laurent, D. Ability of certain plant extracts traditionally used to treat ciguatera fish poisoning to inhibit nitric oxide production in RAW 264.7 macrophages. J.Ethnopharmacol. 6-25-2009;123(3):369-377. View abstract.

Kuritzky, L. Pomegranate juice for erectile dysfunction. Clinical Oncology Alert 2008;13(2):3-4.

Kyralan, M. Gölükcü M. and Tokgöz H. Oil and Conjugated Linolenic Acid Contents of Seeds from Important Pomegranate Cultivars ( Punica granatum L.) Grown in Turkey. Journal of the American Oil Chemists' Society 2009;86(10):1029.

Lai, S., Zhou, Q., Zhang, Y., Shang, J., and Yu, T. [Effects of pomegranate tannins on experimental gastric damages]. Zhongguo Zhong.Yao Za Zhi. 2009;34(10):1290-1294. View abstract.

Lan, J., Lei, F., Hua, L., Wang, Y., Xing, D., and Du, L. Transport behavior of ellagic acid of pomegranate leaf tannins and its correlation with total cholesterol alteration in HepG2 cells. Biomed.Chromatogr. 2009;23(5):531-536. View abstract.

Lansky, E. P. and Newman, R. A. Punica granatum (pomegranate) and its potential for prevention and treatment of inflammation and cancer. J Ethnopharmacol 1-19-2007;109(2):177-206. View abstract.

Larrosa, M., Gonzalez-Sarrias, A., Yanez-Gascon, M. J., Selma, M. V., Azorin-Ortuno, M., Toti, S., Tomas-Barberan, F., Dolara, P., and Espin, J. C. Anti-inflammatory properties of a pomegranate extract and its metabolite urolithin-A in a colitis rat model and the effect of colon inflammation on phenolic metabolism. J.Nutr.Biochem. 2010;21(8):717-725. View abstract.

Lee, S. I., Kim, B. S., Kim, K. S., Lee, S., Shin, K. S., and Lim, J. S. Immune-suppressive activity of punicalagin via inhibition of NFAT activation. Biochem.Biophys.Res.Commun. 7-11-2008;371(4):799-803. View abstract.

Leiva, K. P., Rubio, J., Peralta, F., and Gonzales, G. F. Effect of Punica granatum (pomegranate) on sperm production in male rats treated with lead acetate. Toxicol.Mech.Methods 2011;21(6):495-502. View abstract.

Li, J. Li G. Zhao Y. and Yu C. Composition of pomegranate peel polyphenols and its antioxidant activities. Scientia Agricultura Sinica 2009;42(11):4035-4041.

Li, Z., Percival, S. S., Bonard, S., and Gu, L. Fabrication of nanoparticles using partially purified pomegranate ellagitannins and gelatin and their apoptotic effects. Mol.Nutr.Food Res. 2011;55(7):1096-1103. View abstract.

Lucas, D. L. and Were, L. M. Anti-Listeria monocytogenes activity of heat-treated lyophilized pomegranate juice in media and in ground top round beef. J.Food Prot. 2009;72(12):2508-2516. View abstract.

Martin, K. R. Krueger C. G. Rodriquez G. Dreher M. and Reed J. D. Development of a novel pomegranate standard and new method for the quantitative measurement of pomegranate polyphenols. Journal of the Science of Food and Agriculture 2009;89(1):157-162.

Mattiello, T., Trifiro, E., Jotti, G. S., and Pulcinelli, F. M. Effects of pomegranate juice and extract polyphenols on platelet function. J.Med.Food 2009;12(2):334-339. View abstract.

McCarrell, E. M., Gould, S. W., Fielder, M. D., Kelly, A. F., El, Sankary W., and Naughton, D. P. Antimicrobial activities of pomegranate rind extracts: enhancement by addition of metal salts and vitamin C. BMC.Complement Altern.Med. 2008;8:64. View abstract.

McDougall, G. J., Ross, H. A., Ikeji, M., and Stewart, D. Berry extracts exert different antiproliferative effects against cervical and colon cancer cells grown in vitro. J.Agric.Food Chem. 5-14-2008;56(9):3016-3023. View abstract.

McFarlin, B. K., Strohacker, K. A., and Kueht, M. L. Pomegranate seed oil consumption during a period of high-fat feeding reduces weight gain and reduces type 2 diabetes risk in CD-1 mice. Br.J.Nutr. 2009;102(1):54-59. View abstract.

Melgarejo, P., Salazar, D. M., and Amoros, A. Total lipids content and fatty acid composition of seed oils from six pomegranate cultivars. J.Sci.Food Agr. 1995;69:253-256.

Menezes, S. M., Cordeiro, L. N., and Viana, G. S. Punica granatum (pomegranate) extract is active against dental plaque. J Herb Pharmacother 2006;6(2):79-92. View abstract.

Mirmiran, P., Fazeli, M. R., Asghari, G., Shafiee, A., and Azizi, F. Effect of pomegranate seed oil on hyperlipidaemic subjects: a double-blind placebo-controlled clinical trial. Br.J.Nutr. 2010;104(3):402-406. View abstract.

Mohan, M., Waghulde, H., and Kasture, S. Effect of pomegranate juice on Angiotensin II-induced hypertension in diabetic Wistar rats. Phytother.Res. 2010;24 Suppl 2:S196-S203. View abstract.

Mousavinejad, G. Emam-Djomeh Z. Rezaei K. and Khodaparast M. H. H. Identification and quantification of phenolic compounds and their effects on antioxidant activity in pomegranate juices of eight Iranian cultivars. Food Chemistry 2009;115(4):1274-1278.

Navarro, P. Nicolas T. S. Gabaldon J. A. Mercader-Ros M. T. Calín-Sánchez Á. Carbonell-Barrachina Á. A. and Pérez-López A. J. Effects of Cyclodextrin Type on Vitamin C, Antioxidant Activity, and Sensory Attributes of a Mandarin Juice Enriched with Pomegranate and Goji Berries. Journal of Food Science 2011;76(5):319-324.

Navarro, V., Villarreal, M. L., Rojas, G., and Lozoya, X. Antimicrobial evaluation of some plants used in Mexican traditional medicine for the treatment of infectious diseases. J Ethnopharmacol. 1996;53(3):143-147. View abstract.

Newton, K. M., Reed, S. D., Grothaus, L., Ehrlich, K., Guiltinan, J., Ludman, E., and Lacroix, A. Z. Reprint of The Herbal Alternatives for Menopause (HALT) Study: background and study design. Maturitas 2008;61(1-2):181-193. View abstract.

Newton, K. M., Reed, S. D., Grothaus, L., Ehrlich, K., Guiltinan, J., Ludman, E., and Lacroix, A. Z. The Herbal Alternatives for Menopause (HALT) Study: background and study design. Maturitas 10-16-2005;52(2):134-146. View abstract.

Nishigaki, I. Rajendran P. Venugopal R. Ekambaram G. Sakthisekaran D. and Nishigaki Y. Effect of extract of pomegranate (Punica granatum L.) on glycated protein-iron chelate-induced toxicity: an in vitro study on human umbilical-vein endothelial cells. Journal of Health Science 2008;54(4):441-449.

Niwano, Y., Saito, K., Yoshizaki, F., Kohno, M., and Ozawa, T. Extensive screening for herbal extracts with potent antioxidant properties. J.Clin.Biochem.Nutr. 2011;48(1):78-84. View abstract.

Nualkaekul, S. and Charalampopoulos, D. Survival of Lactobacillus plantarum in model solutions and fruit juices. Int.J.Food Microbiol. 3-30-2011;146(2):111-117. View abstract.

O'May, C. and Tufenkji, N. The swarming motility of Pseudomonas aeruginosa is blocked by cranberry proanthocyanidins and other tannin-containing materials. Appl.Environ.Microbiol. 2011;77(9):3061-3067. View abstract.

Oliveira, R. A., Narciso, C. D., Bisinotto, R. S., Perdomo, M. C., Ballou, M. A., Dreher, M., and Santos, J. E. Effects of feeding polyphenols from pomegranate extract on health, growth, nutrient digestion, and immunocompetence of calves. J.Dairy Sci. 2010;93(9):4280-4291. View abstract.

Orak, H. H. Demirci A. S. and Gümüs T. Antibacterial and antifungal activity of pomegranate (Punica granatum L. cv.) peel. Electronic Journal of Environmental, Agricultural and Food Chemistry 2011;10(3):1958-1969.

Orak, H. H. Evaluation of antioxidant activity, colour and some nutritional characteristics of pomegranate (Punica granatum L.) juice and its sour concentrate processed by conventional evaporation. Int.J.Food Sci.Nutr. 2009;60(1):1-11. View abstract.

Pacheco-Palencia, L. A., Noratto, G., Hingorani, L., Talcott, S. T., and Mertens-Talcott, S. U. Protective effects of standardized pomegranate (Punica granatum L.) polyphenolic extract in ultraviolet-irradiated human skin fibroblasts. J.Agric.Food Chem. 9-24-2008;56(18):8434-8441. View abstract.

Pai, M. B., Prashant, G. M., Murlikrishna, K. S., Shivakumar, K. M., and Chandu, G. N. Antifungal efficacy of Punica granatum, Acacia nilotica, Cuminum cyminum and Foeniculum vulgare on Candida albicans: an in vitro study. Indian J.Dent.Res. 2010;21(3):334-336. View abstract.

Pande, G. and Akoh, C. C. Antioxidant capacity and lipid characterization of six Georgia-grown pomegranate cultivars. J.Agric.Food Chem. 10-28-2009;57(20):9427-9436. View abstract.

Panichayupakaranant, P. Tewtrakul S. and Yuenyongsawad S. Antibacterial, anti-inflammatory and anti-allergic activities of standardised pomegranate rind extract. Food Chemistry 2010;123(2):400-403.

Panichayupakarananta, P., Issuriya, A., Sirikatitham, A., and Wang, W. Antioxidant assay-guided purification and LC determination of ellagic acid in pomegranate peel. J.Chromatogr.Sci. 2010;48(6):456-459. View abstract.

Parashar, A. Gupta C. Gupta S. K. and Kumar A. Antimicrobial ellagitannin from pomegranate (Punica granatum) fruits. International Journal of Fruit Science 2009;9(3):226-231.

Park, H. M., Moon, E., Kim, A. J., Kim, M. H., Lee, S., Lee, J. B., Park, Y. K., Jung, H. S., Kim, Y. B., and Kim, S. Y. Extract of Punica granatum inhibits skin photoaging induced by UVB irradiation. Int.J.Dermatol. 2010;49(3):276-282. View abstract.

Parle, M. and Samal M. K. Neuroprotective effects of pomegranate juice in mice. International Journal of Medical Sciences 2010;2(2):166-169.

Parmar, H. S. and Kar, A. Antidiabetic potential of Citrus sinensis and Punica granatum peel extracts in alloxan treated male mice. Biofactors 2007;31(1):17-24. View abstract.

Parmar, H. S. and Kar, A. Medicinal values of fruit peels from Citrus sinensis, Punica granatum, and Musa paradisiaca with respect to alterations in tissue lipid peroxidation and serum concentration of glucose, insulin, and thyroid hormones. J.Med.Food 2008;11(2):376-381. View abstract.

Pillai, N. R. Anti-diarrhoeal activity of Punica granatum in experimental animals. International Journal of Pharmacognosy 1992;30(3):201-204.

Pirbalouti, A. G., Azizi, S., Koohpayeh, A., and Hamedi, B. Wound healing activity of Malva sylvestris and Punica granatum in alloxan-induced diabetic rats. Acta Pol.Pharm. 2010;67(5):511-516. View abstract.

Prashanth, D., Asha, M. K., and Amit, A. Antibacterial activity of Punica granatum. Fitoterapia 2001;72(2):171-173. View abstract.

Qu, W. Pan Z. L. and Ma H. Extraction modeling and activities of antioxidants from pomegranate marc. Journal of Food Engineering 2010;99(1):16-23.

Rababah, T. M., Banat, F., Rababah, A., Ereifej, K., and Yang, W. Optimization of extraction conditions of total phenolics, antioxidant activities, and anthocyanin of oregano, thyme, terebinth, and pomegranate. J.Food Sci. 2010;75(7):C626-C632. View abstract.

Radjabian, T. Husseini H. F. Karami M. Rasooli I. and Faghihzadeh S. Effect of pomegranate fruit juice and seed oil on serum lipid levels and atherosclerosis development in hypercholesterolemic rabbits. Journal of Medicinal Plants 2008;7(25):93-104, 117.

Rasheed, Z., Akhtar, N., Anbazhagan, A. N., Ramamurthy, S., Shukla, M., and Haqqi, T. M. Polyphenol-rich pomegranate fruit extract (POMx) suppresses PMACI-induced expression of pro-inflammatory cytokines by inhibiting the activation of MAP Kinases and NF-kappaB in human KU812 cells. J.Inflamm.(Lond) 2009;6:1. View abstract.

Rasheed, Z., Akhtar, N., and Haqqi, T. M. Pomegranate extract inhibits the interleukin-1beta-induced activation of MKK-3, p38alpha-MAPK and transcription factor RUNX-2 in human osteoarthritis chondrocytes. Arthritis Res.Ther. 2010;12(5):R195. View abstract.

Rattanachaikunsopon, P. and Phumkhachorn, P. Use of asiatic pennywort Centella asiatica aqueous extract as a bath treatment to control columnaris in Nile tilapia. J.Aquat.Anim Health 2010;22(1):14-20. View abstract.

Rettig, M. B., Heber, D., An, J., Seeram, N. P., Rao, J. Y., Liu, H., Klatte, T., Belldegrun, A., Moro, A., Henning, S. M., Mo, D., Aronson, W. J., and Pantuck, A. Pomegranate extract inhibits androgen-independent prostate cancer growth through a nuclear factor-kappaB-dependent mechanism. Mol.Cancer Ther. 2008;7(9):2662-2671. View abstract.

Rock, W., Rosenblat, M., Miller-Lotan, R., Levy, A. P., Elias, M., and Aviram, M. Consumption of wonderful variety pomegranate juice and extract by diabetic patients increases paraoxonase 1 association with high-density lipoprotein and stimulates its catalytic activities. J.Agric.Food Chem. 9-24-2008;56(18):8704-8713. View abstract.

Romier-Crouzet, B., Van De Walle, J., During, A., Joly, A., Rousseau, C., Henry, O., Larondelle, Y., and Schneider, Y. J. Inhibition of inflammatory mediators by polyphenolic plant extracts in human intestinal Caco-2 cells. Food Chem.Toxicol. 2009;47(6):1221-1230. View abstract.

Rosenblat, M., Draganov, D., Watson, C. E., Bisgaier, C. L., La Du, B. N., and Aviram, M. Mouse macrophage paraoxonase 2 activity is increased whereas cellular paraoxonase 3 activity is decreased under oxidative stress. Arterioscler.Thromb.Vasc.Biol 3-1-2003;23(3):468-474. View abstract.

Rosenblat, M., Volkova, N., Attias, J., Mahamid, R., and Aviram, M. Consumption of polyphenolic-rich beverages (mostly pomegranate and black currant juices) by healthy subjects for a short term increased serum antioxidant status, and the serum's ability to attenuate macrophage cholesterol accumulation. Food Funct. 2010;1(1):99-109. View abstract.

Rosenblat, M., Volkova, N., Coleman, R., and Aviram, M. Pomegranate byproduct administration to apolipoprotein e-deficient mice attenuates atherosclerosis development as a result of decreased macrophage oxidative stress and reduced cellular uptake of oxidized low-density lipoprotein. J Agric Food Chem 3-8-2006;54(5):1928-1935. View abstract.

Rozenberg, O., Howell, A., and Aviram, M. Pomegranate juice sugar fraction reduces macrophage oxidative state, whereas white grape juice sugar fraction increases it. Atherosclerosis 2006;188(1):68-76. View abstract.

Salgado, L. Melgarejo P. Meseguer I. and Sánchez M. Antimicrobial activity of crude extracts from pomegranate (Punica granatum L.). Acta Horticulturae 2009;818:257-264.

Samadloiy, H. R. Azizi M. H. and Barzegar M. Physico-chemical quality of seeds of pomegranate cultivars (Punica granatum L.) grown in Iran and antioxidative activity of their phenolic component. Journal of Food Science and Technology 2008;45(2):190-192.

Sartippour, M. R., Seeram, N. P., Rao, J. Y., Moro, A., Harris, D. M., Henning, S. M., Firouzi, A., Rettig, M. B., Aronson, W. J., Pantuck, A. J., and Heber, D. Ellagitannin-rich pomegranate extract inhibits angiogenesis in prostate cancer in vitro and in vivo. Int.J.Oncol. 2008;32(2):475-480. View abstract.

Saruwatari, A., Okamura, S., Nakajima, Y., Narukawa, Y., Takeda, T., and Tamura, H. Pomegranate juice inhibits sulfoconjugation in Caco-2 human colon carcinoma cells. J.Med.Food 2008;11(4):623-628. View abstract.

Sastravaha, G., Gassmann, G., Sangtherapitikul, P., and Grimm, W. D. Adjunctive periodontal treatment with Centella asiatica and Punica granatum extracts in supportive periodontal therapy. J Int Acad Periodontol. 2005;7(3):70-79. View abstract.

Sayyari, M., Valero, D., Babalar, M., Kalantari, S., Zapata, P. J., and Serrano, M. Prestorage oxalic acid treatment maintained visual quality, bioactive compounds, and antioxidant potential of pomegranate after long-term storage at 2 degrees C. J.Agric.Food Chem. 6-9-2010;58(11):6804-6808. View abstract.

Schwartz, E., Tzulker, R., Glazer, I., Bar-Ya'akov, I., Wiesman, Z., Tripler, E., Bar-Ilan, I., Fromm, H., Borochov-Neori, H., Holland, D., and Amir, R. Environmental conditions affect the color, taste, and antioxidant capacity of 11 pomegranate accessions' fruits. J.Agric.Food Chem. 10-14-2009;57(19):9197-9209. View abstract.

Seeram, N. P., Henning, S. M., Zhang, Y., Suchard, M., Li, Z., and Heber, D. Pomegranate juice ellagitannin metabolites are present in human plasma and some persist in urine for up to 48 hours. J Nutr 2006;136(10):2481-2485. View abstract.

Seeram, N. P., Zhang, Y., McKeever, R., Henning, S. M., Lee, R. P., Suchard, M. A., Li, Z., Chen, S., Thames, G., Zerlin, A., Nguyen, M., Wang, D., Dreher, M., and Heber, D. Pomegranate juice and extracts provide similar levels of plasma and urinary ellagitannin metabolites in human subjects. J.Med.Food 2008;11(2):390-394. View abstract.

Segura, J. J., Morales-Ramos, L. H., Verde-Star, J., and Guerra, D. [Growth inhibition of Entamoeba histolytica and E. invadens produced by pomegranate root (Punica granatum L.)]. Arch Invest Med (Mex.) 1990;21(3):235-239. View abstract.

Seong, A. R., Yoo, J. Y., Choi, K., Lee, M. H., Lee, Y. H., Lee, J., Jun, W., Kim, S., and Yoon, H. G. Delphinidin, a specific inhibitor of histone acetyltransferase, suppresses inflammatory signaling via prevention of NF-kappaB acetylation in fibroblast-like synoviocyte MH7A cells. Biochem.Biophys.Res.Commun. 7-8-2011;410(3):581-586. View abstract.

Sharma, A., Chandraker, S., Patel, V. K., and Ramteke, P. Antibacterial Activity of Medicinal Plants Against Pathogens causing Complicated Urinary Tract Infections. Indian J.Pharm.Sci. 2009;71(2):136-139. View abstract.

Sharma, M., Li, L., Celver, J., Killian, C., Kovoor, A., and Seeram, N. P. Effects of fruit ellagitannin extracts, ellagic acid, and their colonic metabolite, urolithin A, on Wnt signaling. J.Agric.Food Chem. 4-14-2010;58(7):3965-3969. View abstract.

Shiner, M., Fuhrman, B., and Aviram, M. Macrophage paraoxonase 2 (PON2) expression is up-regulated by pomegranate juice phenolic anti-oxidants via PPAR gamma and AP-1 pathway activation. Atherosclerosis 2007;195(2):313-321. View abstract.

Shukla, M., Gupta, K., Rasheed, Z., Khan, K. A., and Haqqi, T. M. Bioavailable constituents/metabolites of pomegranate (Punica granatum L) preferentially inhibit COX2 activity ex vivo and IL-1beta-induced PGE2 production in human chondrocytes in vitro. J.Inflamm.(Lond) 2008;5:9. View abstract.

Shukla, M., Gupta, K., Rasheed, Z., Khan, K. A., and Haqqi, T. M. Consumption of hydrolyzable tannins-rich pomegranate extract suppresses inflammation and joint damage in rheumatoid arthritis. Nutrition 2008;24(7-8):733-743. View abstract.

Simsek, N. Karadeniz A. and Bayraktaroglu A. G. Effects of L-carnitine, royal jelly and pomegranate seed on peripheral blood cells in rats. / Ratlarda periferal kan hücreleri üzerine L-karnitin, ar sütü ve nar cekirdeginin etkileri. Kafkas Üniversitesi. Veteriner Fakültesi Dergisi 2009;15(1):63-69.

Singh, K., Jaggi, A. S., and Singh, N. Exploring the ameliorative potential of Punica granatum in dextran sulfate sodium induced ulcerative colitis in mice. Phytother.Res. 2009;23(11):1565-1574. View abstract.

Song, W. Jiao S. Zhou J. and Ye C. Microwaves assisted extraction of polyphenol from pomegranate peel and its antioxidant and antimicrobial activities. Modern Food Science and Technology 2008;24(1):23-27.

Stowe, C. B. The effects of pomegranate juice consumption on blood pressure and cardiovascular health. Complement Ther.Clin.Pract. 2011;17(2):113-115. View abstract.

Su, X., Sangster, M. Y., and D'Souza, D. H. In vitro effects of pomegranate juice and pomegranate polyphenols on foodborne viral surrogates. Foodborne.Pathog.Dis. 2010;7(12):1473-1479. View abstract.

Sundararajan, A., Ganapathy, R., Huan, L., Dunlap, J. R., Webby, R. J., Kotwal, G. J., and Sangster, M. Y. Influenza virus variation in susceptibility to inactivation by pomegranate polyphenols is determined by envelope glycoproteins. Antiviral Res. 2010;88(1):1-9. View abstract.

Syed, D. N., Malik, A., Hadi, N., Sarfaraz, S., Afaq, F., and Mukhtar, H. Photochemopreventive effect of pomegranate fruit extract on UVA-mediated activation of cellular pathways in normal human epidermal keratinocytes. Photochem Photobiol 2006;82(2):398-405. View abstract.

Tanner, A. E. Saker K. E. Ju Y. Lee Y. W. O'Keefe S. Robertson J. and Tanko J. M. Cell proliferation of feline and human breast cancer cell types is inhibited by pomegranate juice. Journal of Animal Physiology & Animal Nutrition 2008;92(2):221-222.

Tayel, A. A. and El-Tras, W. F. Anticandidal activity of pomegranate peel extract aerosol as an applicable sanitizing method. Mycoses 3-1-2010;53(2):117-122. View abstract.

Tayel, A. A., Salem, M. F., El-Tras, W. F., and Brimer, L. Exploration of Islamic medicine plant extracts as powerful antifungals for the prevention of mycotoxigenic Aspergilli growth in organic silage. J.Sci.Food Agric. 2011;91(12):2160-2165. View abstract.

Thring, T. S., Hili, P., and Naughton, D. P. Anti-collagenase, anti-elastase and anti-oxidant activities of extracts from 21 plants. BMC.Complement Altern Med 2009;9:27. View abstract.

Toi, M., Bando, H., Ramachandran, C., Melnick, S. J., Imai, A., Fife, R. S., Carr, R. E., Oikawa, T., and Lansky, E. P. Preliminary studies on the anti-angiogenic potential of pomegranate fractions in vitro and in vivo. Angiogenesis. 2003;6(2):121-128. View abstract.

Tran, H. N., Bae, S. Y., Song, B. H., Lee, B. H., Bae, Y. S., Kim, Y. H., Lansky, E. P., and Newman, R. A. Pomegranate (Punica granatum) seed linolenic acid isomers: concentration-dependent modulation of estrogen receptor activity. Endocr.Res. 2010;35(1):1-16. View abstract.

Trombold, J. R., Barnes, J. N., Critchley, L., and Coyle, E. F. Ellagitannin consumption improves strength recovery 2-3 d after eccentric exercise. Med.Sci.Sports Exerc. 2010;42(3):493-498. View abstract.

Trombold, J. R., Reinfeld, A. S., Casler, J. R., and Coyle, E. F. The effect of pomegranate juice supplementation on strength and soreness after eccentric exercise. J.Strength.Cond.Res. 2011;25(7):1782-1788. View abstract.

Trottier, G., Bostrom, P. J., Lawrentschuk, N., and Fleshner, N. E. Nutraceuticals and prostate cancer prevention: a current review. Nat.Rev.Urol. 2010;7(1):21-30. View abstract.

Tu, H. Liu D. and Xiong X. Y. Oil extract from pomegranate seed and its composition analysis. Progress in Modern Biomedicine 2008;8(11):2107-2108, 2125.

Tugcu, V., Kemahli, E., Ozbek, E., Arinci, Y. V., Uhri, M., Erturkuner, P., Metin, G., Seckin, I., Karaca, C., Ipekoglu, N., Altug, T., Cekmen, M. B., and Tasci, A. I. Protective effect of a potent antioxidant, pomegranate juice, in the kidney of rats with nephrolithiasis induced by ethylene glycol. J.Endourol. 2008;22(12):2723-2731. View abstract.

Turk G, Sonmez M, Aydin M, Yuce A, Gur S, Yuksel M, Aksu EH, and Aksoy H. Effects of pomegranate juice consumption on sperm quality, spermatogenic cell density, antioxidant activity and testosterone level in male rats. Clinical Nutrition 2008;27(2):289-296.

Turk, G., Sonmez, M., Aydin, M., Yuce, A., Gur, S., Yuksel, M., Aksu, E. H., and Aksoy, H. Effects of pomegranate juice consumption on sperm quality, spermatogenic cell density, antioxidant activity and testosterone level in male rats. Clin.Nutr. 2008;27(2):289-296. View abstract.

Vroegrijk, I. O., van Diepen, J. A., van den Berg, S., Westbroek, I., Keizer, H., Gambelli, L., Hontecillas, R., Bassaganya-Riera, J., Zondag, G. C., Romijn, J. A., Havekes, L. M., and Voshol, P. J. Pomegranate seed oil, a rich source of punicic acid, prevents diet-induced obesity and insulin resistance in mice. Food Chem.Toxicol. 2011;49(6):1426-1430. View abstract.

Wang, F., Huang, W., Zhang, S., Liu, G., Li, K., and Tang, B. Enhancing fluorescence intensity of Ellagic acid in Borax-HCl-CTAB micelles. Spectrochim.Acta A Mol.Biomol.Spectrosc. 2011;78(3):1013-1017. View abstract.

Wang, L., Alcon, A., Yuan, H., Ho, J., Li, Q. J., and Martins-Green, M. Cellular and molecular mechanisms of pomegranate juice-induced anti-metastatic effect on prostate cancer cells. Integr.Biol.(Camb.) 2011;3(7):742-754. View abstract.

Weisburg, J. H., Schuck, A. G., Silverman, M. S., Ovits-Levy, C. G., Solodokin, L. J., Zuckerbraun, H. L., and Babich, H. Pomegranate extract, a prooxidant with antiproliferative and proapoptotic activities preferentially towards carcinoma cells. Anticancer Agents Med.Chem. 10-1-2010;10(8):634-644. View abstract.

Wolfe, K. L., Kang, X., He, X., Dong, M., Zhang, Q., and Liu, R. H. Cellular antioxidant activity of common fruits. J.Agric.Food Chem. 9-24-2008;56(18):8418-8426. View abstract.

Wongwattanasathien, O., Kangsadalampai, K., and Tongyonk, L. Antimutagenicity of some flowers grown in Thailand. Food Chem.Toxicol 2010;48(4):1045-1051. View abstract.

Wright, H. and Pipkin F. B. Pomegranates (Punica granatum), kiwifruit (Actinidia deliciosa) and blood pressure: a pilot study. Proceedings of the Nutrition Society 2008;67(8):1.

Xie, Y., Morikawa, T., Ninomiya, K., Imura, K., Muraoka, O., Yuan, D., and Yoshikawa, M. Medicinal flowers. XXIII. New taraxastane-type triterpene, punicanolic acid, with tumor necrosis factor-alpha inhibitory activity from the flowers of Punica granatum. Chem.Pharm.Bull.(Tokyo) 2008;56(11):1628-1631. View abstract.

Xu, K. Z., Zhu, C., Kim, M. S., Yamahara, J., and Li, Y. Pomegranate flower ameliorates fatty liver in an animal model of type 2 diabetes and obesity. J.Ethnopharmacol. 6-22-2009;123(2):280-287. View abstract.

Yldz, H. Obuz E. and Bayraktaroglu G. Pomegranate: its antioxidant activity and its effect on health. Acta Horticulturae 2009;818:265-270.

Zahin, M., Aqil, F., and Ahmad, I. Broad spectrum antimutagenic activity of antioxidant active fraction of punica granatum L. peel extracts. Mutat.Res. 12-21-2010;703(2):99-107. View abstract.

Zahin, M., Hasan, S., Aqil, F., Khan, M. S., Husain, F. M., and Ahmad, I. Screening of certain medicinal plants from India for their anti-quorum sensing activity. Indian J.Exp.Biol. 2010;48(12):1219-1224. View abstract.

Zhang L., Fu Q. and Zhang Y. Composition of anthocyanins in pomegranate flowers and their antioxidant activity. Food Chemistry 2011;127(4):1444-1449.

Zhang, J., Zhan, B., Yao, X., Gao, Y., and Shong, J. [Antiviral activity of tannin from the pericarp of Punica granatum L. against genital Herpes virus in vitro]. Zhongguo Zhong.Yao Za Zhi. 1995;20(9):556-8, 576, inside. View abstract.

Zhang, L. H. Li L. L. Li Y. X. and Zhang Y. H. In vitro antioxidant activities of fruits and leaves of Pomegranate. Acta Horticulturae 2008;765:31-34.

Zhang, Q., Radisavljevic, Z. M., Siroky, M. B., and Azadzoi, K. M. Dietary antioxidants improve arteriogenic erectile dysfunction. Int.J.Androl 2011;34(3):225-235. View abstract.

Zhao, G. Li G. Dong Z. and Liu X. Study on antioxidant activity and extraction of polyphenols from pomegranate seed. Acta Botanica Boreali-Occidentalia Sinica 2008;28(12):2532-2537.

Zheng, X. Liu B. Li L. Zhu X. Microwave-assisted extraction and antioxidant activity of total phenolic compounds from pomegranate peel. Journal of Medicinal Plants Research 2011;5(6):1004-1011.

Zhu, J. Yu L. Zhang L. Cui X. Ai H. Effect of water extraction from pomegranate peel on cardiac electrical activity of Bufo Bufo Gargarizans in vivo. Food and Drug 2009;11(9):22-25.

Zhuang, H. Du J. and Wang Y. Antioxidant Capacity Changes of 3 Cultivar Chinese Pomegranate ( Punica granatum L.) Juices and Corresponding Wines. Journal of Food Science 2011;76(4):606-611.

Abedini M, Ghasemi-Tehrani H, Tarrahi MJ, Amani R. The effect of concentrated pomegranate juice consumption on risk factors of cardiovascular diseases in women with polycystic ovary syndrome: A randomized controlled trial. Phytother Res. 2021;35(1):442-451. View abstract.

Adel-Mehraban MS, Tansaz M, Mohammadi M, Yavari M. Effects of pomegranate supplement on menopausal symptoms and quality of life in menopausal women: A double-blind randomized placebo-controlled trial. Complement Ther Clin Pract 2022;46:101544. View abstract.

Ajaikumar KB, Asheef M, Babu BH, Padikkala J. The inhibition of gastric mucosal injury by Punicagranatum L. (pomegranate) methanolic extract. J Ethnopharmacol 2005;96:171-6. View abstract.

Albrecht M, Jiang W, Kumi-Diaka J, et al. Pomegranate extracts potently suppress proliferation, xenograft growth, and invasion of human prostate cancer cells. J Med Food 2004;7:274-83. View abstract.

Aslam MN, Lansky EP, Varani J. Pomegranate as a cosmeceutical source: Pomegranate fractions promote proliferation and procollagen synthesis and inhibit matrix metalloproteinase-1 production in human skin cells. J Ethnopharmacol 2006;103:311-8. View abstract.

Auerbach L, Rakus J, Bauer C, et al. Pomegranate seed oil in women with menopausal symptoms: a prospective randomized, placebo-controlled, double-blinded trial. Menopause 2012;19(4):426-32. View abstract.

Aviram M, Dornfeld L. Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure. Atherosclerosis 2001;158:195-8. View abstract.

Aviram M, Rosenblat M, Gaitini D, et al. Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation. Clin Nutr 2004;23:423-33. View abstract.

Aviram M. Polyphenolic flavonoids content and anti-oxidant activities of various juices: a comparative study. Proceedings of the 11th Biennial Meeting of the Society for Free Radical Research International, 2002 Feb:1-9.

Azadzoi KM, Schulman RN, Aviram M, Siroky MB. Oxidative stress in arteriogenic erectile dysfunction: prophylactic role of antioxidants. J Urol 2005;174:386-93. View abstract.

Balbir-Gurman A, Fuhrman B, Braun-Moscovici Y, et al. Consumption of pomegranate decreases serum oxidative stress and reduces disease activity in patients with active rheumatoid arthritis: a pilot study. Isr Med Assoc J 2011;13(8):474-9. View abstract.

Banihani SA, Makahleh SM, El-Akawi Z, et al. Fresh pomegranate juice ameliorates insulin resistance, enhances ß-cell function, and decreases fasting serum glucose in type 2 diabetic patients. Nutr Res 2014;34(10):862-7. View abstract.

Barati Boldaji R, Akhlaghi M, Sagheb MM, Esmaeilinezhad Z. Pomegranate juice improves cardiometabolic risk factors, biomarkers of oxidative stress and inflammation in hemodialysis patients: a randomized crossover trial. J Sci Food Agric. 2020;100(2):846-854. View abstract.

Basic report: 09286, pomegranates, raw. National Nutrient Database for Standard Reference Release 28. USDA Web site. Available at: https://ndb.nal.usda.gov/ndb/foods/show/2359?fgcd=&manu=&lfacet=&format=&count=&max=35&offset=&sort=&qlookup=pomegranate. Accessed June 1, 2016.

Braga LC, Shupp JW, Cummings C, et al. Pomegranate extract inhibits Staphylococcus aureus growth and subsequent enterotoxin production. J Ethnopharmacol 2005;96:335-9. View abstract.

Cerda B, Soto C, Albaladejo MD, et al. Pomegranate juice supplementation in chronic obstructive pulmonary disease: a 5-week randomized, double-blind, placebo-controlled trial. Eur J Clin Nutr 2006;60:245-53. View abstract.

Crum EM, Barnes MJ, Stannard SR. Multiday pomegranate extract supplementation decreases oxygen uptake during submaximal cycling exercise, but cosupplementation with N-acetylcysteine negates the effect. Int J Sport Nutr Exerc Metab. 2018;28(6):586-592. View abstract.

Davidson MH, Maki KC, Dicklin MR, et al. Effects of consumption of pomegranate juice on carotid intima-media thickness in men and women at moderate risk for coronary heart disease. Am J Cardiol 2009;104:936-42. View abstract.

de Nigris F, Williams-Ignarro S, Lerman LO, et al. Beneficial effects of pomegranate juice on oxidation-sensitive genes and endothelial nitric oxide synthase activity at sites of perturbed shear stress. Proc Natl Acad Sci U S A 2005;102:4896-901. View abstract.

Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182

Enrique E, Utz M, De Mateo JA, et al. Allergy to lipid transfer proteins: cross-reactivity among pomegranate, hazelnut, and peanut. Ann Allergy Asthma Immunol 2006;96(1):122-3. View abstract.

Esmaeilinezhad Z, Babajafari S, Sohrabi Z, Eskandari MH, Amooee S, Barati-Boldaji R. Effect of synbiotic pomegranate juice on glycemic, sex hormone profile and anthropometric indices in PCOS: A randomized, triple blind, controlled trial. Nutr Metab Cardiovasc Dis. 2019;29(2):201-208. View abstract.

Esmaillzadeh A, Tahbaz F, Gaieni I, et al. Concentrated pomegranate juice improves lipid profiles in diabetic patients with hyperlipidemia. J Med Food 2004;7:305-8. View abstract.

Farkas D, Greenblatt DJ. Influence of fruit juices on drug disposition: discrepancies between in vitro and clinical studies. Expert Opin Drug Metab Toxicol 2008;4:381-93. View abstract.

Farkas D, Oleson LE, Zhao Y, et al. Pomegranate juice does not impair clearance of oral or intravenous midazolam, a probe for cytochrome P450-3A activity: comparison with grapefruit juice. J Clin Pharmacol 2007;47:286-94. View abstract.

Farnsworth N, Bingel A, Cordell G, et al. Potential value of plants as sources of new antifertility agents I. J Pharm Sci 1975;64:535-98. View abstract.

Ferrara L, Schettino O, Forgione P, et al. [Identification of the root of Punica granatum in galenic preparations using TLC]. Boll Soc Ital Biol Sper 1989;65:385-90. View abstract.

Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press, 2000. Available at: https://www.nap.edu/books/0309069351/html/.

Gaig P, Bartolome B, Lleonart R, et al. Allergy to pomegranate (Punica granatum). Allergy 1999;54:287-8. View abstract.

Gangemi S, Mistrello G, Roncarolo D, et al. Pomegranate-dependent exercise-induced anaphylaxis. J Investig Allergol Clin Immunol 2008;18:491-2. View abstract.

Gheflati A, Mohammadi M, Ramezani-Jolfaie N, Heidari Z, Salehi-Abargouei A, Nadjarzadeh A. Does pomegranate consumption affect weight and body composition? A systematic review and meta-analysis of randomized controlled clinical trials. Phytother Res. 2019;33(5):1277-1288. View abstract.

Gil MI, Tomas-Barberan FA, Hess-Pierce B, et al. Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing. J Agric Food Chem 2000;48:4581-9. View abstract.

Gonzalez-Ortiz M, Martinez-Abundis E, Espinel-Bermudez MC, Perez-Rubio KG. Effect of pomegranate juice on insulin secretion and sensitivity in patients with obesity. Ann Nutr Metab 2013;58(3):220-3. View abstract.

González-Sarrías A, Romo-Vaquero M, García-Villalba R, Cortés-Martín A, Selma MV, Espín JC. The endotoxemia marker lipopolysaccharide-binding protein is reduced in overweight-obese subjects consuming pomegranate extract by modulating the gut microbiota: A randomized clinical trial. Mol Nutr Food Res. 2018;62(11):e1800160. View abstract.

Goodarzi R, Jafarirad S, Mohammadtaghvaei N, Dastoorpoor M, Alavinejad P. The effect of pomegranate extract on anthropometric indices, serum lipids, glycemic indicators, and blood pressure in patients with nonalcoholic fatty liver disease: A randomized double-blind clinical trial. Phytother Res 2021;35(10):5871-5882. View abstract.

Haidari M, Ali M, Ward Casscells S 3rd, Madjid M. Pomegranate (Punica granatum) purified polyphenol extract inhibits influenza virus and has a synergistic effect with oseltamivir. Phytomedicine 2009;16:1127-36. View abstract.

Hanley MJ, Masse G, Harmatz JS, et al. Pomegranate juice and pomegranate extract do not impair oral clearance of flurbiprofen in human volunteers: divergence from in vitro results. Clin Pharmacol Ther 2012;92(5):651-7. View abstract.

Heber D, Seeram NP, Wyatt H, et al. Safety and antioxidant activity of pomegranate ellagitannin-enriched polyphenol dietary supplement in overweight individuals with increased waist size. J Agric Food Chem 2007;55:10050-4. View abstract.

Hidaka M, Okumura M, Fujita K, et al. Effects of pomegranate juice on human cytochrome p450 3A (CYP3A) and carbamazepine pharmacokinetics in rats. Drug Metab Dispos 2005;33:644-8. View abstract.

Holetz FB, Pessini GL, Sanches NR, et al. Screening of some plants used in the Brazilian folk medicine for the treatment of infectious diseases. Mem Inst Oswaldo Cruz 2002;97:1027-31. View abstract.

Hora JJ, Maydew ER, Lansky EP, Dwivedi C. Chemopreventive effects of pomegranate seed oil on skin tumor development in CD1 mice. J Med Food 2003;6:157-61. View abstract.

Huang TH, Yang Q, Harada M, et al. Pomegranate flower extract diminishes cardiac fibrosis in Zucker diabetic fatty rats: modulation of cardiac endothelin-1 and nuclear factor-kappaB pathways. J Cardiovasc Pharmacol 2005;46:856-62. . View abstract.

Igea JM, Cuesta J, Cuevas M, et al. Adverse reaction to pomegranate ingestion. Allergy 1991;46:472-4. View abstract.

Israeli A, Grinblat G, Shochat I, Sarid M, Dudkiewicz M, Braverman I. Clinical Efficacy of Topical Nasal Pomegranate Fruit Extract for Chronic Rhinitis and Chronic Rhinosinusitis. Ear Nose Throat J 2021. View abstract.

Jandari S, Hatami E, Ziaei R, Ghavami A, Yamchi AM. The effect of pomegranate (Punica granatum) supplementation on metabolic status in patients with type 2 diabetes: A systematic review and meta-analysis. Complement Ther Med. 2020;52:102478. View abstract.

Jarrard D, Filon M, Huang W, et al. A phase II randomized placebo-controlled trial of pomegranate fruit extract in men with localized prostate cancer undergoing active surveillance. Prostate. 2021;81(1):41-49. View abstract.

Jarvis S, Li C, Bogle RG. Possible interaction between pomegranate juice and warfarin. Emerg Med J 2010;27:74-5. View abstract.

Jeune MA, Kumi-Diaka J, Brown J. Anticancer activities of pomegranate extracts and genistein in human breast cancer cells. J Med Food 2005;8:469-75. View abstract.

Kaplan M, Hayek T, Raz A, et al. Pomegranate juice supplementation to atherosclerotic mice reduces macrophage lipid peroxidation, cellular cholesterol accumulation and development of atherosclerosis. J Nutr 2001;131:2082-9. View abstract.

Kim ND, Mehta R, Yu W, et al. Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer. Breast Cancer Res Treat 2002;71:203-17. View abstract.

Komperda KE. Potential interaction between pomegranate juice and warfarin. Pharmacotherapy 2009;29:1002-6. View abstract.

Lamb KL, Ranchordas MK, Johnson E, Denning J, Downing F, Lynn A. No effect of tart cherry juice or pomegranate juice on recovery from exercise-induced muscle damage in non-resistance trained men. Nutrients. 2019;11(7). pii: E1593. View abstract.

Langley P. Why a pomegranate? BMJ 2000;321:1153-4. View abstract.

Lei F, Zhang XN, Wang W, et al. Evidence of anti-obesity effects of the pomegranate leaf extract in high-fat diet induced obese mice. Int J Obes 2007;31:1023-9. View abstract.

Li Y, Wen S, Kota BP, et al. Punica granatum flower extract, a potent alpha-glucosidase inhibitor, improves postprandial hyperglycemia in Zucker diabetic fatty rats. J Ethnopharmacol 2005;99:239-44. View abstract.

Longtin R. The pomegranate: nature's power fruit? J Natl Cancer Inst 2003;95:346-8. View abstract.

Loren DJ, Seeram NP, Schulman RN, Holtzman DM. Maternal dietary supplementation with pomegranate juice is neuroprotective in an animal model of neonatal hypoxic-ischemic brain injury. Pediatr Res 2005;57:858-64. View abstract.

Lorzadeh E, Heidary Z, Mohammadi M, Nadjarzadeh A, Ramezani-Jolfaie N, Salehi-Abargouei A. Does pomegranate consumption improve oxidative stress? A systematic review and meta-analysis of randomized controlled clinical trials. Clin Nutr ESPEN 2022;47:117-127. View abstract.

Malik A, Afaq F, Sarfaraz S, et al. Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer. Proc Natl Acad Sci USA 2005;102:14813-8. View abstract.

Miguel G, Dandlen S, Antunes D, et al. The effect of two methods of pomegranate (Punica granatum L) juice extraction on quality during storage at 4°C. J Biomed Biotechnol 2004;5:332-7. View abstract.

Misaka S, Nakamura R, Uchida S, et al. Effect of 2 weeks' consumption of pomegranate juice on the pharmacokinetics of a single dose of midazolam: an open-label, randomized, single-center, 2-period crossover study in healthy Japanese volunteers. Clin Ther 2011;33:246-52. View abstract.

Moneam NM, el Sharaky AS, Badreldin MM. Oestrogen content of pomegranate seeds. J Chromatogr 1988;438:438-42. View abstract.

Murthy KN, Reddy VK, Veigas JM, Murthy UD. Study on wound healing activity of Punica granatum peel. J Med Food 2004;7:256-9. View abstract.

Nagata M, Hidaka M, Sekiya H, et al. Effects of pomegranate juice on human cytochrome P450 2C9 and tolbutamide pharmacokinetics in rats. Drug Metab Dispos 2007;35:302-5. View abstract.

Neurath AR, Strick N, Li YY, Debnath AK. Punica granatum (pomegranate) juice provides an HIV-1 entry inhibitor and candidate topical microbicide. Ann N Y Acad Sci 2005;1056:311-27. View abstract.

Neurath AR, Strick N, Li YY, Debnath AK. Punica granatum (Pomegranate) juice provides an HIV-1 entry inhibitor and candidate topical microbicide. BMC Infect Dis 2004;4:41. View abstract.

Noda Y, Kaneyuki T, Mori A, Packer L. Antioxidant activities of pomegranate fruit extract and its anthocyanidins: delphinidin, cyanidin, and pelargonidin. J Agric Food Chem 2002;50:166-71. View abstract.

Paller CJ, Ye X, Wozniak PJ, et al. A randomized phase II study of pomegranate extract for men with rising PSA following initial therapy for localized prostate cancer. Prostate Cancer Prostatic Dis 2013;16(1):50-5. View abstract.

Pantuck AJ, Leppert JT, Zomorodian N, et al. Phase II study of pomegranate juice for men with rising prostate-specific antigen following surgery or radiation for prostate cancer. Clin Cancer Res 2006;12:4018-26. View abstract.

Pantuck AJ, Pettaway CA, Dreicer R, et al. A randomized, double-blind, placebo-controlled study of the effects of pomegranate extract on rising PSA levels in men following primary therapy for prostate cancer. Prostate Cancer Prostatic Dis. 2015;18(3):242-8. View abstract.

Pantuck AJ, Zomorodian N, Belldegrun AS. Phase-II Study of pomegranate juice for men with prostate cancer and increasing PSA. Curr Urol Rep 2006;7:7. View abstract.

Park SJ, Yeo CW, Shim EJ, et al. Pomegranate juice does not affect the disposition of simvastatin in healthy subjects. Eur J Drug Metab Pharmacokinet 2016;41(4):339-44. View abstract.

Rivara MB, Mehrotra R, Linke L, et al. A pilot randomized crossover trial assessing the safety and short-term effects of pomegranate supplementation in hemodialysis patients. J Ren Nutr 2015;25(1):40-9. View abstract.

Rosenblat M, Hayek T, Aviram M. Anti-oxidative effects of pomegranate juice (PJ) consumption by diabetic patients on serum and on macrophages. Atherosclerosis 2006;187:363-71. View abstract.

Ross MM, Cherkerzian S, Mikulis ND, et al. A randomized controlled trial investigating the impact of maternal dietary supplementation with pomegranate juice on brain injury in infants with IUGR. Sci Rep. 2021;11(1):3569. View abstract.

Sahebkar A, Ferri C, Giorgini P, Bo S, Nachtigal P, Grassi D. Effects of pomegranate juice on blood pressure: a systematic review and meta-analysis of randomized controlled trials. Pharmacol Res. 2017 Jan;115:149-61. View abstract.

Sahebkar A, Simental-Mendia LE, Giorgini P, Ferri C, Grassi D. Lipid profile changes after pomegranate consumption: a systematic review and meta-analysis of randomized controlled trials. Phytomedicine. 2016 Oct 15;23(11):1103-12.View abstract.

Sastravaha G, Yotnuengnit P, Booncong P, Sangtherapitikul P. Adjunctive periodontal treatment with Centella asiatica and Punica granatum extracts. A preliminary study. J Int Acad Periodontol 2003;5:106-15. View abstract.

Schubert SY, Lansky EP, Neeman I. Antioxidant and eicosanoid enzyme inhibition properties of pomegranate seed oil and fermented juice flavonoids. J Ethnopharmacol 1999;66:11-7. View abstract.

Seeram NP, Adams LS, Henning SM, et al. In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice. J Nutr Biochem 2005;16:360-7. View abstract.

Selim MI, Popendorf W, Ibrahim MS, et al. Aflatoxin B1 in common Egyptian foods. J AOAC Int 1996;79(5):1124-9. View abstract.

Seyed Hashemi M, Namiranian N, Tavahen H, et al. Efficacy of pomegranate seed powder on glucose and lipid metabolism in patients with type 2 diabetes: A prospective randomized double-blind placebo-controlled clinical trial. Complement Med Res. 2021;28(3):226-233. View abstract.

Shema-Didi L, Sela S, Ore L, et al. One year of pomegranate juice intake decreases oxidative stress, inflammation, and incidence of infections in hemodialysis patients: a randomized placebo-controlled trial. Free Radic Biol Med 2012;53(2):297-304. View abstract.

Shemi-Didi L, Kristal B, Sela S, et al. Does pomegranate intake attenuate cardiovascular risk factors in hemodialysis patients? Nutr J 2014;13:18. View abstract.

Sohrab G, Sotoodeh G, Siasi F, et al. Effect of pomegranate juice consumption on blood pressure in type 2 diabetic patients. Iranian Journal of Endocrinology and Metabolism 2008;9:399-405, 470.

Sorokin AV, Duncan B, Panetta R, Thompson PD. Rhabdomyolysis associated with pomegranate juice consumption. Am J Cardiol 2006;98:705-6. View abstract.

Sreeramaneni PGA, Yalamanchi A, Konda MR, Cherukuri SHV, Maroon JC. A Proprietary Herbal Blend Containing Extracts of Punica granatum Fruit Rind and Theobroma cocoa Seeds Increases Serum Testosterone Level in Healthy Young Males: A Randomized, Double-Blind Placebo-Controlled Study. J Diet Suppl 2022. View abstract.

Sumner MD, Elliott-Eller M, Weidner G, et al. Effects of pomegranate juice consumption on myocardial perfusion in patients with coronary heart disease. Am J Cardiol 2005;96:810-4. View abstract.

Thomas R, Williams M, Sharma H, Chaudry A, Bellamy P. A double-blind, placebo-controlled randomised trial evaluating the effect of a polyphenol-rich whole food supplement on PSA progression in men with prostate cancer--the U.K. NCRN Pomi-T study. Prostate Cancer Prostatic Dis 2014;17(2):180-6. View abstract.

Torregrosa-García A, Ávila-Gandía V, Luque-Rubia AJ, Abellán-Ruiz MS, Querol-Calderón M, López-Román FJ. Pomegranate extract improves maximal performance of trained cyclists after an exhausting endurance trial: A randomised controlled trial. Nutrients. 2019;11(4). pii: E721. View abstract.

Tripathi SM, Singh DK. Molluscicidal activity of Punica granatum bark and Canna indica root. Braz J Med Biol Res 2000;33:1351-5. View abstract.

Valsecchi R, Reseghetti A, Leghissa P, et al. Immediate contact hypersensitivity to pomegranate. Contact Dermatitis 1998;38:44-5. View abstract.

Vasconcelos LC, Sampaio MC, Sampaio FC, Higino JS. Use of Punica granatum as an antifungal agent against candidosis associated with denture stomatitis. Mycoses 2003;46:192-6. View abstract.

Vidal A, Fallarero A, Pena BR, et al. Studies on the toxicity of Punica granatum L. (Punicaceae) whole fruit extracts. J Ethnopharmacol 2003;89:295-300. View abstract.

Voravuthikunchai SP, Kitpipit L. Activity of medicinal plant extracts against hospital isolates of methicillin-resistant Staphylococcus aureus. Clin Microbiol Infect 2005;11:510-2. View abstract.

Wang P, Zhang Q, Hou H, et al. The effects of pomegranate supplementation on biomarkers of inflammation and endothelial dysfunction: A meta-analysis and systematic review. Complement Ther Med. 2020;49:102358. View abstract.

Wang RF, Xie WD, Zhang Z, et al. Bioactive compounds from the seeds of Punica granatum (pomegranate). J Nat Prod 2004;67:2096-8. View abstract.

Yeo C, Shon J, Liu K, et al. The effects of pomegranate juice on the pharmacokinetics of simvastatin in healthy Korean subjects (PI-63). Clin Pharmacol Ther 2006;79:23.

Zhang Y, Krueger D, Durst R, et al. International multidimensional authenticity specification (IMAS) algorithm for detection of commercial pomegranate juice adulteration. J Agric Food Chem 2009;57(6):2550-7. View abstract.

Zhang Y, Wang D, Lee RP, et al. Absence of pomegranate ellagitannins in the majority of commercial pomegranate extracts: implications for standardization and quality control. J Agric Food Chem 2009;57(16):7395-400. View abstract.

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