I identify 4-Benzyloxy-2-methylphenylboronic acid, CAS 847560-49-0, as a substituted aryl boronic acid primarily used as a research and synthetic building block. Its most established role is as an organoboron intermediate for carbon–carbon bond-forming chemistry, especially Suzuki–Miyaura coupling, where the arylboronic acid group can react with a suitable aryl or vinyl electrophile under an appropriate catalytic system. The benzyloxy substituent and methyl group provide additional structural features that can be retained, transformed, or evaluated during route development.
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I recommend treating this material as a project-specific research reagent rather than assuming that one universal application or performance profile applies to every synthesis. The compound is commonly described by the molecular formula C14H15BO3 and an approximate molecular weight of 242.08 g/mol, while the exact commercial specification should always be confirmed through the current certificate of analysis and safety data sheet.
The boronic acid group is the key reactive handle in this molecule. In a Suzuki–Miyaura reaction, it may serve as the aryl component that transfers its substituted phenyl group to an organic partner such as an aryl halide or related electrophile. The precise reaction outcome depends on the coupling partner, palladium catalyst, base, solvent, temperature, concentration, and work-up conditions, so I do not regard the reagent as a guaranteed solution without route-specific validation.
This function makes 4-Benzyloxy-2-methylphenylboronic acid useful during medicinal chemistry, process research, and the preparation of specialized aromatic intermediates. Researchers may select it when they need to introduce a phenyl ring containing both a methyl substituent and a benzyloxy-protected oxygen functionality. The boronic acid group can then be consumed during coupling, leaving the other substituents available for subsequent synthetic steps.
The benzyloxy group can be viewed as a protected phenolic oxygen arrangement. In a multi-step synthesis, this may allow the oxygen substituent to remain differentiated from the boronic acid during earlier transformations, followed by deprotection when a free phenol is required. Whether deprotection is suitable depends on the substrate, hydrogenolysis conditions, catalyst compatibility, and the stability of other functional groups in the molecule.
The 2-methyl substituent also contributes to the identity of the building block. It changes the electronic and steric environment around the aromatic ring, which can influence reaction optimization and the properties of the final coupled product. I recommend confirming those effects experimentally rather than inferring yield, selectivity, or scalability from the chemical name alone.
In medicinal chemistry, this compound may be used to introduce a substituted aromatic fragment into a candidate molecule or screening library. The coupling approach can support modular assembly, allowing a researcher to vary the partner used with the boronic acid while maintaining the 4-benzyloxy-2-methylphenyl portion. This can be valuable when a project is exploring structure–activity relationships around an aromatic region.
Its use in discovery work does not mean that the compound itself is an active pharmaceutical ingredient or that it has established biological activity. I describe it as a synthetic intermediate, and any biological property belongs to the final molecule produced after further chemistry and evaluation. Researchers should therefore use appropriate analytical confirmation, including methods such as HPLC, NMR, or mass spectrometry, according to their internal protocols.
Process chemists may evaluate this boronic acid when developing a scalable route to a more complex aryl compound. At this stage, the important questions include reaction conversion, impurity formation, filtration behavior, isolation method, and compatibility with the selected coupling system. A small-scale reaction that gives acceptable conversion may still require further work before it is considered suitable for larger laboratory or manufacturing-oriented development.
The compound can also function as a route-screening reagent. A development team may compare it with alternative protected or unprotected hydroxyaryl boronic acids to determine which material provides the best balance of reactivity, handling, purification, and downstream flexibility. I recommend recording the complete reaction context because isolated performance is not determined by the reagent name alone.
Outside medicinal chemistry, the material may be considered for the preparation of specialty aromatic intermediates, research compounds, and advanced building blocks. Its value comes from combining a transferable aryl boronic acid group with a protected oxygen substituent and an additional methyl group in one defined structure. The final suitability depends on the target architecture and the transformations planned after coupling.
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When sourcing this product, I distinguish the exact compound from related materials that may look similar in a catalog. Possible alternatives include the corresponding unprotected hydroxyaryl boronic acid, a different benzyl-protected isomer, or an aryl halide used in a complementary coupling route. These alternatives are not automatically interchangeable because substitution position, protection state, and functional-group identity can change reactivity and purification requirements.
| Material consideration | Why it matters |
|---|---|
| Exact identity | Confirm the name, CAS 847560-49-0, structure, and molecular formula before ordering. |
| Assay and impurity profile | Review the stated assay method and relevant impurities for the intended reaction. |
| Protection state | Determine whether the benzyloxy group can remain through the route or must be removed later. |
| Physical presentation | Check appearance, packaging, storage guidance, and handling information in the product documents. |
I advise buyers to begin with identity and documentation rather than price alone. The product name should match 4-Benzyloxy-2-methylphenylboronic acid, and the CAS number should be listed as 847560-49-0. A supplier should also be able to provide a current specification sheet, batch-specific certificate of analysis when available, and safety data sheet for internal review.
Assay is an important purchasing parameter, but the stated percentage should be interpreted together with the analytical method and impurity limits. Buyers may also need information on water content, residual solvents, elemental impurities, or physical form, depending on the sensitivity of their route. I do not recommend assuming that a catalog assay represents an identical result across all batches or analytical laboratories.
Storage and transport conditions should be reviewed before shipment. The packaging size may be offered in quantities such as 1 g, 5 g, or larger project-specific amounts, but available pack sizes and minimum order quantities can vary by supplier and destination. Since boronic acids can show behavior that depends on structure and storage history, I recommend requesting the supplier’s current handling guidance rather than applying an undocumented shelf-life assumption.
First, I compare the exact substitution pattern with the target route. A positional isomer or a different protection group may produce a different product or require a different deprotection strategy. I also check whether the planned coupling conditions are compatible with the benzyloxy group and with any sensitive functionality in the reaction partner.
For research procurement, clear documentation helps the laboratory assess identity and repeatability. I look for a product specification, analytical data, lot identification, packaging details, and safety documentation before confirming a purchase. For regulated or quality-sensitive projects, the buyer should communicate any additional document requirements at the quotation stage because not every supplier package is identical.
Lead time, stock status, minimum order quantity, shipping destination, and packaging should be evaluated together. A low unit price may not be advantageous if the required quantity is unavailable or if the delivery schedule does not fit the synthesis plan. I encourage buyers to request a quotation based on their intended quantity, target delivery location, and documentation needs.
At Maison Chemical, I position this product for customers who need a defined organic boronic acid intermediate for research, route scouting, or specialty synthesis. I can help organize an inquiry around the compound identity, required quantity, preferred packaging, destination, and documentation expectations. This allows the commercial discussion to focus on the buyer’s actual project requirements rather than on a generic catalog request.
Before placing an order, I recommend confirming current availability, batch information, specification details, and shipping conditions with Maison Chemical. If the requested quantity or specification is not immediately available, the sourcing team can review the project requirements and clarify feasible supply options without making unsupported claims about performance or certification.
4-Benzyloxy-2-methylphenylboronic acid CAS 847560-49-0 is mainly used as a substituted aryl boronic acid building block in research and organic synthesis. Its principal value is the combination of a coupling-capable boronic acid group, a benzyloxy-protected aromatic oxygen function, and a methyl substituent in one molecule. Typical evaluation areas include Suzuki–Miyaura coupling, medicinal chemistry library construction, process-route research, and the preparation of specialty aromatic intermediates.
The next step is to compare the exact structure with your synthetic route, define the required quantity and documentation, and confirm the current batch specification before purchase. For a project quotation or technical sourcing discussion, contact Maison Chemical with CAS 847560-49-0, your target quantity, delivery location, and any analytical or packaging requirements. This information enables a more precise and practical B2B response.
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