3,4,5-Trifluorophenylboronic acid is an aromatic boronic acid used primarily as a building block in synthetic chemistry, especially for palladium-catalyzed Suzuki–Miyaura coupling. It contains a phenyl ring substituted with fluorine atoms at the 3, 4, and 5 positions and a boronic acid group that can participate in carbon–carbon bond formation. Its CAS Registry Number is 143418-49-9, and its molecular formula is commonly represented as C6H4BF3O2. At Maison Chemical, I support B2B buyers by helping them evaluate identity, specification, documentation, packaging, and supply requirements before purchase.
3,4,5-Trifluorophenylboronic acid belongs to the family of organic boronic acids. The boronic acid functional group provides a reactive boron center, while the trifluorinated aromatic ring contributes a defined electronic and steric environment that can influence reaction behavior. The compound is generally supplied as a research or manufacturing intermediate rather than as a finished pharmaceutical ingredient.
The calculated molecular weight is approximately 175.90 g/mol. This value is useful when converting between mass and molar quantities during reaction planning; for example, 1 mmol corresponds to approximately 175.90 mg before accounting for purity, assay, or any moisture content. Buyers should still confirm the supplier’s specification and analytical documentation because commercial material may differ in appearance, residual solvent content, or measured assay.
The principal function of 3,4,5-trifluorophenylboronic acid is to serve as an aryl transfer reagent in cross-coupling chemistry. Under a suitable catalytic system, the aryl group can be coupled with an appropriate aryl, heteroaryl, or vinyl halide to form a new carbon–carbon bond. The exact yield and reaction performance depend on the electrophile, palladium catalyst, base, solvent, temperature, concentration, and work-up conditions.
The boronic acid group is valuable because it is often compatible with a wide range of synthetic routes and can be introduced at a defined stage of a molecule-building process. The three fluorine substituents may alter lipophilicity, metabolic behavior, acidity, and electronic properties in the final compound. These effects are molecule-dependent, so I recommend treating the material as a strategic intermediate rather than assuming that fluorination guarantees a specific performance outcome.
Beyond cross-coupling, this compound may be used in medicinal chemistry, agrochemical research, materials research, and route-development programs that require a trifluorinated aromatic fragment. It can help researchers construct more complex small molecules while retaining the fluorinated ring in the final structure. Its suitability should be confirmed through laboratory evaluation because the presence of a boronic acid group does not eliminate the need for reaction optimization.
In pharmaceutical and medicinal chemistry, 3,4,5-trifluorophenylboronic acid may be selected for the preparation of substituted biaryl or heteroaryl compounds during discovery and process research. It is particularly relevant when a project requires a controlled combination of an aromatic boronic acid handle and a highly fluorinated ring. The material may be used at early screening scale, route scouting scale, or later process-development scale, subject to project-specific quality requirements.
In agrochemical research, fluorinated aromatic intermediates are often considered when researchers are designing molecules with targeted physicochemical properties. In materials and specialty chemical research, the compound may also be used to introduce a fluorinated aryl segment into larger molecular architectures. These are potential application areas, not guaranteed end uses, and the buyer should assess regulatory, safety, and technical requirements for the intended product.
| Specification area | Why it matters |
|---|---|
| Identity | Confirm the chemical name, CAS number 143418-49-9, molecular formula, and structure. |
| Assay or purity | Higher and consistently measured purity can reduce uncertainty during reaction development. |
| Water content | Boronic acids may be sensitive to moisture-related variability, depending on the application. |
| Residual solvents | Residual solvent limits may be important for regulated or scale-up projects. |
| Appearance and physical form | Color, powder condition, and handling behavior should match the agreed specification. |
| Analytical documents | Review the certificate of analysis, chromatographic data, and available spectroscopy records. |
I advise buyers not to rely on the product name alone. The purchase specification should state the required assay method, impurity profile, packaging format, storage conditions, retest policy, and documentation package. If the material is intended for a regulated development program, the quality agreement and change-control expectations should be discussed before commercial supply begins.
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Handling should follow the supplier’s current safety data sheet and the buyer’s internal chemical safety procedures. Personnel should use suitable personal protective equipment, avoid generating dust, and work with appropriate ventilation. Because the practical stability of a boronic acid can depend on moisture, temperature, packaging, and storage duration, I recommend confirming the recommended storage range and retest period for each specific batch.
For laboratory use, chemists should consider the material’s assay and water content when calculating the required mass. A nominal 100 mg portion is not necessarily equivalent to 100 mg of active compound if the batch contains moisture or impurities. Buyers should also confirm whether the product is packed under a dry atmosphere, sealed with a moisture barrier, or supplied in another packaging configuration suited to the intended application.
Discovery research may prioritize availability, small quantities, and rapid technical confirmation, while process development usually requires tighter impurity control, batch consistency, and stronger documentation. A buyer moving from milligram or gram-scale work to larger quantities should not assume that the same specification and packaging are automatically appropriate. I recommend defining the required quantity range, target purity, critical impurities, delivery location, and expected annual demand before requesting a quotation.
Minimum order quantity and lead time can vary according to stock status, production scheduling, packaging, and whether the request is for standard or customized material. A supplier should clearly distinguish between available inventory, production lead time, and estimated dispatch timing. Buyers should also ask whether a pre-shipment sample, reserve sample, or batch-specific certificate can be provided when these controls are important to the project.
A capable supplier should be able to discuss product identification, analytical documentation, packaging, shipping requirements, and inquiry-specific quality expectations. For repeat orders, the buyer should seek clarity on batch-to-batch consistency and notification procedures for significant manufacturing or specification changes. At Maison Chemical, I approach each inquiry by aligning the proposed supply option with the customer’s application, quantity, documentation, and delivery requirements rather than offering an unsuitable standard package.
3,4,5-Trifluorophenylboronic acid is a defined fluorinated aromatic boronic acid intermediate with the CAS number 143418-49-9 and an approximate molecular weight of 175.90 g/mol. Its main synthetic value comes from its use as an aryl donor in Suzuki–Miyaura coupling and as a building block for fluorinated small molecules. The correct purchase decision depends not only on the chemical name, but also on assay, moisture, impurity profile, packaging, documentation, quantity, and delivery requirements.
If you need 3,4,5-trifluorophenylboronic acid for research, route development, or manufacturing, begin by defining the required specification and intended scale. Then compare suppliers on verified identity, analytical support, packaging suitability, MOQ, lead time, and communication quality. I can help you review the technical requirements and prepare a supply option for your project through Maison Chemical.
For a quotation or technical discussion, send your required quantity, target purity, destination, packaging preference, and documentation needs. I will use that information to support a practical B2B sourcing evaluation without assuming that one specification fits every application.
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