4-Aminophenylboronic acid picol ester CAS 214360-73-3 is commonly associated with the aryl boronate ester also known as 4-aminophenylboronic acid pinacol ester or 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline. It is an aromatic boronic ester that combines a reactive boron-containing coupling group with a para-amino functional group. In practical terms, I regard it as a useful organic building block for medicinal chemistry, pharmaceutical intermediate research, materials development, and other laboratory-scale synthesis programs.
The CAS number supplied for this product is 214360-73-3. The commonly reported molecular formula for the pinacol ester structure is C12H18BNO2, with a molecular weight of approximately 219.09 g/mol. Because commercial naming can vary between “picol” and “pinacol,” I recommend confirming the structure, formula, analytical specification, and safety documentation before placing a purchase order.
This compound contains an aniline-type amino group attached to a phenyl ring and an aryl boronic ester group at the para position. The boronate portion contains 1 boron atom per molecule, while the amino group provides an additional functional handle for chemical transformation. This combination allows the material to participate in different synthetic routes rather than serving only as an inert aromatic intermediate.
The boronic ester is generally selected because it is a convenient protected form of an aryl boronic acid. In suitable palladium-catalyzed cross-coupling chemistry, the aryl boronate can react with compatible electrophilic partners to form new carbon–carbon bonds. The amino group may also be protected, acylated, alkylated, or used in other transformations, depending on the reaction design.
“Picol ester” is sometimes used incorrectly or inconsistently in commercial searches for this product, while “pinacol ester” is the more commonly encountered description for the tetramethyl dioxaborolane structure. I do not recommend relying on the product name alone when comparing suppliers. A buyer should check the CAS number, structural drawing, molecular formula, molecular weight, and certificate of analysis as one connected identity set.
The primary function of 4-aminophenylboronic acid pinacol ester is to provide a functionalized aryl fragment for bond-forming chemistry. Its boronate group is frequently considered for Suzuki–Miyaura coupling or related transformations, although actual reaction performance depends on the reaction partners, catalyst system, solvent, base, temperature, and purification method. The compound’s amino group also enables downstream diversification after or before coupling.
From a project-planning perspective, this dual functionality can reduce the need to build the aromatic intermediate from the beginning. A research chemist may use the compound to introduce a para-aminophenyl unit into a more complex target structure. The material can therefore be relevant to discovery chemistry, route scouting, process development, and the preparation of advanced reference compounds.
In medicinal chemistry, researchers may use this building block to prepare analogues containing an aniline-derived aromatic segment. The boronate group can support the introduction of heteroaryl, aryl, or other compatible fragments through established coupling strategies. The amino group can then be incorporated into urea, amide, sulfonamide, or related structures when the target design requires those linkages.
For process chemistry teams, the compound may be evaluated during route selection or scale-up studies. Important questions include whether the boronate remains stable under the planned storage and reaction conditions, whether the amino group requires protection, and whether residual palladium or other impurities could affect the next step. These decisions should be based on project-specific experiments rather than on the name of the intermediate alone.
The para-amino group and aryl boronate function can also be of interest in the preparation of functional aromatic molecules and research materials. Suitability depends on the required molecular architecture, polymerization route, and sensitivity of the target application. I recommend treating this use as application-dependent and confirming compatibility through small-scale laboratory evaluation.
Suppliers may offer this material in different package sizes, purity grades, and documentation levels. For early discovery work, a standard research grade may be sufficient, while route development or regulated supply chains may require tighter impurity controls, lot traceability, and more detailed analytical records. The appropriate specification is determined by the intended reaction and the downstream quality requirements.
Goto Maison Chemical to know more.
| Specification or document | What I recommend checking |
|---|---|
| Identity | CAS 214360-73-3, chemical name, structural representation, and formula |
| Molecular data | Approximately 219.09 g/mol for the commonly reported pinacol ester structure |
| Purity | HPLC, GC, NMR, or another stated method; confirm whether the specification is ≥98% or ≥99% |
| Physical description | Reported appearance, color range, form, and lot-specific observations |
| Residual impurities | Water, solvents, metals, and related boronate or amino impurities where relevant |
| Documentation | Certificate of analysis, safety data sheet, lot number, and packaging information |
I would not assume that a stated purity percentage is directly comparable between suppliers unless the analytical method and calculation basis are also provided. A material listed at 98% by one method may not be equivalent to a material listed at 98% by another method. For a sensitive synthesis, I suggest requesting a recent lot-specific COA before confirming the order.
As an organic boronate ester and aromatic amine, this product should be handled according to the supplier’s current safety data sheet. Laboratory personnel should use appropriate gloves, eye protection, ventilation, and contamination controls, especially when weighing powders or transferring material. The exact hazard classification, recommended storage conditions, and transport requirements must come from the product-specific SDS rather than from a generic assumption about boronic esters.
Many laboratory chemicals are kept in a controlled, dry environment, often around 15–25°C, unless the supplier specifies another range. Moisture, heat, repeated container opening, and unsuitable packaging can affect the practical stability of sensitive intermediates. I recommend keeping the container tightly closed, minimizing exposure to humidity, and recording the lot and opening date for internal quality control.
The first purchasing step is to verify that the quoted material is the intended para-amino aryl pinacol boronate rather than a positional isomer, a deprotected boronic acid, or another related compound. Ask for the structural formula and CAS number together. If the supplier uses the term “picol ester,” request clarification of the intended ester structure in writing.
For exploratory reactions, buyers may prioritize availability, small pack sizes, and a practical purity specification. For repeated synthesis or scale-up, I would place greater emphasis on lot consistency, impurity profiles, analytical method transparency, and supply continuity. If the material will enter a regulated development process, the supplier’s change-control and documentation practices should also be reviewed.
Price is only one part of the total sourcing decision. I recommend checking minimum order quantity, available package sizes, production or replenishment lead time, export documentation, packaging suitability, and the supplier’s ability to provide a retained sample or pre-shipment documents when required. A reliable supplier should communicate clearly about what is standard stock, what is made to order, and what must be confirmed after production.
At Maison Chemical, we support B2B buyers evaluating 4-Aminophenylboronic acid picol ester CAS 214360-73-3 for research, intermediate synthesis, and international procurement. I can help organize the key information needed for a technical comparison, including product identity, available purity, packaging, lot documentation, and shipping requirements. Where the product name is ambiguous, I recommend resolving the nomenclature before commercial confirmation.
Our approach is to align the offered material with the buyer’s actual use rather than provide a one-size-fits-all quotation. You can specify your target quantity, preferred purity, destination country, documentation requirements, and expected purchasing schedule. This allows us to assess the most appropriate supply option and identify any points that require technical confirmation.
In direct answer to the question, 4-Aminophenylboronic acid picol ester CAS 214360-73-3 is a functionalized aromatic boronate building block, generally identified in the market as 4-aminophenylboronic acid pinacol ester. Its value comes from the combination of a coupling-capable boronate group and a chemically useful amino group. The best buying decision depends on verified identity, application-appropriate purity, documentation quality, and dependable supply rather than on the product name or price alone.
As a next step, prepare your required quantity, purity target, destination, packaging preference, and documentation list. Send these details to Maison Chemical for a focused quotation and technical review. We can then help you confirm whether the offered specification is appropriate for your synthesis or research program before you commit to a larger order.
If you are looking for more details, kindly visit 4-Aminophenylboronic acid picol ester CAS 214360-73-3.