Pyridine-4-boronic acid, CAS 1692-15-5, is an aromatic boronic acid used primarily as a building block in palladium-catalyzed Suzuki–Miyaura coupling and related synthetic chemistry. Its key value is the combination of a boronic acid functional group with a pyridine nitrogen, allowing chemists to introduce a pyridinyl fragment into pharmaceutical, agrochemical, and advanced intermediate structures. At Maison Chemical, we support B2B buyers by helping them verify identity, grade, packaging, documentation, and supply conditions before purchase.
The compound is commonly identified by the molecular formula C5H6BNO2 and a calculated molecular weight of approximately 122.92 g/mol. However, the most suitable commercial specification depends on the intended reaction, scale, storage period, and analytical requirements. Buyers should therefore evaluate the current Certificate of Analysis, not rely only on a catalog name or CAS number.
This guide is intended for pharmaceutical and medicinal chemistry teams, custom synthesis companies, academic laboratories, process development groups, and chemical distributors. It is especially relevant when a procurement team needs a reliable source of Pyridine-4-boronic acid rather than a small research quantity from an unverified marketplace. It can also help buyers compare direct supply, distributor sourcing, and alternative protected boronate options.
I recommend using this information as a technical purchasing framework rather than as a substitute for project-specific validation. Reaction performance can change with solvent, base, catalyst, substrate, water content, and storage history. A supplier should provide batch-specific information whenever the material is being used in a regulated or scale-sensitive process.
Pyridine-4-boronic acid is a heteroaryl boronic acid in which the boronic acid group is attached to the 4-position of a pyridine ring. The boronic acid moiety can participate in carbon–carbon bond-forming reactions, while the pyridine nitrogen remains available to influence polarity, coordination, and downstream molecular properties. This structural combination makes the material useful for preparing substituted pyridines and other nitrogen-containing intermediates.
Its chemical identity should be confirmed using the CAS number 1692-15-5 together with molecular formula, molecular weight, appearance, assay, and analytical data. The material may be supplied as a solid, but appearance alone is not sufficient for quality release. For technical evaluation, I suggest checking at least NMR, HPLC or another appropriate purity method, water content where relevant, and residual solvents when specified by the purchasing standard.
The primary synthetic application is cross-coupling with aryl or heteroaryl halides, typically under a palladium catalyst and a suitable base. This reaction can form a new carbon–carbon bond and introduce a pyridin-4-yl group into a more complex molecule. The exact reaction outcome depends on the substrate and process conditions, so a successful literature reaction should not be treated as a guaranteed result for every manufacturing route.
Pyridine-containing fragments are widely used in medicinal chemistry because the ring nitrogen can affect hydrogen bonding, polarity, and binding interactions. Pyridine-4-boronic acid can therefore serve as a convenient intermediate for analog generation and structure–activity relationship studies. In early-stage work, small quantities may be sufficient, while process development usually requires tighter control of impurity profiles, lot consistency, and delivery timing.
The compound may also be considered for the preparation of heteroaryl intermediates used in specialty chemicals and agrochemical research. Its suitability depends on the required substitution pattern and the compatibility of the boronic acid with the chosen route. Buyers should provide the target structure or reaction scheme when requesting a quotation, because this allows the supplier to discuss the most appropriate grade or an alternative such as a protected boronate ester.
The following specification points should be confirmed before placing a B2B order. Some values are product- and batch-dependent, so Maison Chemical provides them according to the available grade and production documentation rather than presenting one universal specification for every application.
| Specification Item | Why It Matters |
|---|---|
| CAS number: 1692-15-5 | Confirms the intended chemical identity during purchasing and import documentation. |
| Formula: C5H6BNO2 | Supports identity review, molecular calculations, and reaction stoichiometry. |
| Molecular weight: approximately 122.92 g/mol | Used for weighing, equivalent calculations, and process scale-up planning. |
| Assay and impurity profile | Helps determine whether the grade is suitable for discovery, development, or manufacturing work. |
| Water and residual solvent information | Important because moisture and volatile residues may affect reaction reproducibility. |
| Packaging and storage guidance | Supports material protection during warehouse storage and international transport. |
For a first technical screen, I suggest requesting the product specification, a representative or batch-specific CoA, SDS, available analytical data, and recommended storage conditions. The calculated molecular weight is approximately 122.92 g/mol, but the buyer should use the supplier’s approved documentation for final formulation or manufacturing records. If the compound is sensitive in the intended process, ask whether a protected form should also be evaluated.
The free boronic acid is often selected when the reaction development team wants to use the direct coupling reagent. In other cases, a protected boronate ester may offer different handling or storage characteristics, although it is not chemically identical and must be assessed independently. The decision should be based on reaction performance, stability requirements, available process data, and the cost of any deprotection step.
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Buyers should also distinguish between research-grade material and a specification designed for process use. Research quantities may prioritize availability and basic identity testing, whereas larger projects may require defined impurity limits, controlled packaging, change notification, and traceable lot documentation. Maison Chemical can review the intended application and recommend a practical inquiry specification without assuming that one grade fits every project.
Start by sharing the CAS number, required quantity, target purity, application, and whether the material will enter a regulated or manufacturing process. Include any limits for water, residual solvents, metals, or specific related substances if they are critical to your route. This information helps prevent quotations that appear comparable but are based on different quality levels.
Ask for an SDS, specification sheet, and CoA format before purchase whenever possible. Check whether the test methods are identified and whether the reported results correspond to the shipped lot. For recurring supply, also ask how the supplier manages lot traceability and whether technical changes are communicated in advance.
Packaging should protect the material from unsuitable exposure during storage and transport, while the label should clearly show product name, CAS number, lot information, net weight, and handling details. Confirm whether the quoted lead time refers to stock availability, production scheduling, or dispatch time. International buyers should also review documentation requirements, customs classification, and the destination country’s import rules.
Price should be evaluated together with quantity, grade, packaging, payment terms, shipping method, and expected delivery date. MOQ and lead time are not universal values for this product because they can vary by inventory status, packaging format, destination, and order size. At Maison Chemical, we provide a quotation after reviewing these variables so that the commercial offer reflects the actual requirement.
One common mistake is selecting a product solely because the catalog name and CAS number match. Identity is essential, but it does not establish suitability for a sensitive coupling reaction or a manufacturing process. A second mistake is ignoring storage and transport conditions, particularly when the material will remain in inventory for an extended period.
Another avoidable issue is comparing a small research pack with a bulk quotation without checking the analytical package and packaging standard. Buyers may also overlook the difference between free Pyridine-4-boronic acid and a protected boronate ester. I recommend confirming the exact chemical form, required quantity, release tests, and delivery point in writing before approving a purchase order.
Maison Chemical supplies organic boronic acid products for research, development, and commercial sourcing discussions. Our support focuses on product identification, specification alignment, documentation review, packaging coordination, and export-oriented communication. We do not treat a standard product page as a complete technical qualification; instead, we encourage buyers to provide the intended use and acceptance criteria.
For repeat projects, we can discuss forecast quantities, preferred pack sizes, delivery schedules, and the documentation needed by your purchasing or quality team. Where the free boronic acid does not match the project’s stability or handling requirements, we can also help compare relevant material options. Final suitability remains subject to the buyer’s own reaction testing and quality approval process.
Pyridine-4-boronic acid CAS 1692-15-5 is a practical building block for synthetic routes that require a pyridin-4-yl fragment, particularly in Suzuki–Miyaura coupling and related research. The right buying decision depends not only on the chemical name, but also on batch documentation, purity requirements, moisture control, packaging, and supply continuity. A careful comparison of these factors reduces the risk of purchasing a nominally correct material that does not fit the process.
To request a B2B quotation from Maison Chemical, prepare the required quantity, target specification, application, destination, preferred packaging, and delivery schedule. We can then review the requirement, provide available technical documents, and discuss the most suitable supply option for your project. Contact our sales team for a product and commercial assessment tailored to your Pyridine-4-boronic acid sourcing needs.
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