HYALURONIC ACID: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

19 Aug.,2022

 

Sodium hyaluronate

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Bardellini E, Amadori F, Schumacher RF, D'Ippolito C, Porta F, Majorana A. Efficacy of a solution composed by verbascoside, polyvinylpyrrolidone (PVP) and sodium hyaluronate in the treatment of chemotherapy-induced oral mucositis in children with acute lymphoblastic leukemia. J Pediatr Hematol Oncol. 2016;38(7):559-62. View abstract.

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Campanati A, De Blasio S, Giuliano A, et al. Topical ozonated oil versus hyaluronic gel for the treatment of partial- to full-thickness second-degree burns: A prospective, comparative, single-blind, non-randomised, controlled clinical trial. Burns 2013;39(6):1178-83. View abstract.

Chen CP, Hung W, Lin SH. Effectiveness of hyaluronic acid for treating diabetic foot: a systematic review and meta-analysis. Dermatol Ther. 2014;27(6):331-6. View abstract.

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Delia P, Sansotta G, Pontoriero A, et al. Clinical Evaluation of Low-Molecular-Weight Hyaluronic Acid-Based Treatment on Onset of Acute Side Effects in Women Receiving Adjuvant Radiotherapy after Cervical Surgery: A Randomized Clinical Trial. Oncol Res Treat. 2019;42(4):217-223. View abstract.

Disphanurat W, Srisantithum B. Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial. J Cosmet Dermatol 2021;20(11):3563-3572. View abstract.

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Goddard JC, Janssen DAW. Intravesical hyaluronic acid and chondroitin sulfate for recurrent urinary tract infections: systematic review and meta-analysis. Int Urogynecol J. 2018 Jul;29(7):933-942. Epub 2017 Nov 27. Review. View abstract.

Goldberg LD, Crysler C. A single center, pilot, double-blinded, randomized, comparative, prospective clinical study to evaluate improvements in the structure and function of facial skin with tazarotene 0.1% cream alone and in combination with GliSODin Skin Nutrients Advanced Anti-Aging Formula. Clin Cosmet Investig Dermatol. 2014;7:139-44. View abstract.

Gualdi G, Monari P, Cammalleri D, Pelizzari L, Calzavara-Pinton P. Hyaluronic Acid-based Products are Strictly Contraindicated in Scleroderma-related Skin Ulcers. Wounds. 2019;31(3):81-84. View abstract.

Hashem AS, Issrani R, Elsayed TEE, Prabhu N. Topical hyaluronic acid in the management of oral lichen planus: A comparative study. J Investig Clin Dent 2019;10(2):e12385. View abstract.

Humbert P, Mikosinki J, Benchikhi H, Allaert FA. Efficacy and safety of a gauze pad containing hyaluronic acid in treatment of leg ulcers of venous or mixed origin: a double-blind, randomised, controlled trial. Int Wound J 2013;10(2):159-66. View abstract.

Hyalgan Prescribing Information. Sanofi-Synthelabo, Inc. New York, NY, 2002.

Kavouni A, Stanec JJ. Human antihyaluronic acid antibodies. Dermatol Surg 2002;28:359-60. View abstract.

King SR, Hickerson WL, Proctor KG. Beneficial actions of exogenous hyaluronic acid on wound healing. Surgery 1991;109:76-84. View abstract.

Kramer K, Senninger N, Herbst H, Probst W. Effective prevention of adhesions with hyaluronate. Arch Surg 2002;137:278-82. View abstract.

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López-de la Rosa A, Pinto-Fraga J, Blázquez Arauzo F, Urbano Rodríguez R, González-García MJ. Safety and efficacy of an artificial tear containing 0.3% hyaluronic acid in the management of moderate-to-severe dry eye disease. Eye Contact Lens. 2017;43(6):383-388. View abstract.

Makino ET, Tan P, Qian K, Babcock M, Mehta RC. Clinical Assessment of Immediate and Long-Term Effects of a Two-Step Topical Hyaluronic Acid Lip Treatment. J Drugs Dermatol 2017;16(4):366-371. View abstract.

Mikosinski J, Di Landro A, Luczak-Szymerska K, et al. Efficacy and Safety of a Hyaluronic Acid-Containing Gauze Pad in the Treatment of Chronic Venous or Mixed-Origin Leg Ulcers: A Prospective, Multicenter, Randomized Controlled Trial. Wounds 2021;33(6):147-157. View abstract.

Mozzanica F, Preti A, Gera R, et al. Double-blind, randomised controlled trial on the efficacy of saline nasal irrigation with sodium hyaluronate after endoscopic sinus surgery. J Laryngol Otol. 2019;133(4):300-308. View abstract.

Nelson FR, Zvirbulis RA, Zonca B, et al. The effects of an oral preparation containing hyaluronic acid (Oralvisc) on obese knee osteoarthritis patients determined by pain, function, bradykinin, leptin, inflammatory cytokines, and heavy water analyses. Rheumatol Int. 2015;35(1):43-52. View abstract.

New Product: Gelclair concentrated oral gel. Pharmacist's Letter/Prescriber's Letter 2002;18(7):180711.

Nolan A, Badminton J, Maguire J, Seymour RA. The efficacy of topical hyaluronic acid in the management of oral lichen planus. J Oral Pathol Med 2009;38(3):299-303. View abstract.

Nolan A, Baillie C, Badminton J, Rudralingham M, Seymour RA. The efficacy of topical hyaluronic acid in the management of recurrent aphthous ulceration. J Oral Pathol Med 2006;35(8):461-5. View abstract.

Ocak E, Mulazimoglu S, Kocaoz D, Mirici E, Dagli E, Acar A. Effect of adjunctive sodium hyaluronate versus surfactant nasal irrigation on mucociliary clearance in allergic rhinitis: a single-blind, randomised, controlled study. J Laryngol Otol 2021;135(6):529-532. View abstract.

Origoni M, Cimmino C, Carminati G, et al. Postmenopausal vulvovaginal atrophy (VVA) is positively improved by topical hyaluronic acid application. A prospective, observational study. Eur Rev Med Pharmacol Sci. 2016;20(20):4190-4195. View abstract.

Palmieri B, Merighi A, Corbascio D, Rottigni V, Fistetto G, Esposito A. Fixed combination of hyaluronic acid and chondroitin-sulphate oral formulation in a randomized double blind, placebo controlled study for the treatment of symptoms in patients with non-erosive gastroesophageal reflux. Eur Rev Med Pharmacol Sci 2013;17(24):3272-8. View abstract.

Park Y, Song JS, Choi CY, Yoon KC, Lee HK, Kim HS. A randomized multicenter study comparing 0.1%, 0.15%, and 0.3% sodium hyaluronate with 0.05% cyclosporine in the treatment of dry eye. J Ocul Pharmacol Ther. 2017;33(2):66-72. View abstract.

Percival SP. Complications from use of sodium hyaluronate (Healonid) in anterior segment surgery. Br J Ophthalmol 1982;66:714-6. View abstract.

Percival SP. Sodium hyaluronate in perspective: experiences from a four-year clinical trial. Trans Ophthalmol Soc U K 1985;104:616-20. View abstract.

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Pinnix C, Perkins GH, Strom EA, et al. Topical hyaluronic acid vs. standard of care for the prevention of radiation dermatitis after adjuvant radiotherapy for breast cancer: single-blind randomized phase III clinical trial. Int J Radiat Oncol Biol Phys 2012;83(4):1089-94. View abstract.

Pinto-Fraga J, López-de la Rosa A, Blázquez Arauzo F, Urbano Rodríguez R, González-García MJ. Efficacy and safety of 0.2% hyaluronic acid in the management of dry eye disease. Eye Contact Lens. 2017;43(1):57-63. View abstract.

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Ruggiero T, Pol R, Camisassa D, et al. Use of sodium hyaluronate and synthetic amino acid precursors of collagen for the symptomatic treatment of mucositis in patients undergoing haematopoietic stem cell transplants. J Biol Regul Homeost Agents. 2016;30(3):889-894. View abstract.

Ruusuvaara P, Pajari S, Setala K. Effect of sodium hyaluronate on immediate postoperative intraocular pressure after extracapsular cataract extraction and IOL implantation. Acta Ophthalmol (Copenh) 1990;68:721-7. View abstract.

Savarino V, Pace F2, Scarpignato C; Esoxx Study Group. Randomised clinical trial: mucosal protection combined with acid suppression in the treatment of non-erosive reflux disease - efficacy of Esoxx, a hyaluronic acid-chondroitin sulphate based bioadhesive formulation. Aliment Pharmacol Ther. 2017;45(5):631-642. View abstract.

Savietto E, Marioni G, Maculan P, et al. Effectiveness of micronized nasal irrigations with hyaluronic acid/isotonic saline solution in non-polipoid chronic rhinosinusitis: A prospective, randomized, double-blind, controlled study. Am J Otolaryngol. 2020;41(4):102502. View abstract.

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Schwartz SR, Park J. Ingestion of BioCell Collagen, a novel hydrolyzed chicken sternal cartilage extract; enhanced blood microcirculation and reduced facial aging signs. Clin Interv Aging. 2012;7:267-273. View abstract.

Serati M, Bogani G, Di Dedda MC, et al. A comparison between vaginal estrogen and vaginal hyaluronic for the treatment of dyspareunia in women using hormonal contraceptive. Eur J Obstet Gynecol Reprod Biol 2015;191:48-50. View abstract.

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Torella M, Del Deo F, Grimaldi A, et al. Efficacy of an orally administered combination of hyaluronic acid, chondroitin sulfate, curcumin and quercetin for the prevention of recurrent urinary tract infections in postmenopausal women. Eur J Obstet Gynecol Reprod Biol. 2016;207:125-128. View abstract.

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Wei M, Zou Y, Duan F, et al. Efficacy of Long-term Use of 0.3% Sodium Hyaluronate Eye Drops for Traumatic Corneal Abrasion: A Randomized Controlled, Pilot Trial. Cornea 2021;40(10):1248-1252. View abstract.

Yang YJ, Lee WY, Kim YJ, Hong YP. A Meta-Analysis of the Efficacy of Hyaluronic Acid Eye Drops for the Treatment of Dry Eye Syndrome. Int J Environ Res Public Health 2021;18(5):2383. View abstract.

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