CAS 25655-41-8 refers to povidone-iodine, an iodine–povidone complex used primarily as an antiseptic and antimicrobial active ingredient. For B2B purchasing, the CAS number alone is not enough to define a complete product specification. I recommend confirming the grade, available iodine content, physical form, intended application, packaging, and regulatory documentation before placing an order. A common commercial reference is a 10% povidone-iodine solution containing approximately 1% available iodine, but the exact concentration and formulation must be verified on the supplier’s specification sheet and Certificate of Analysis (CoA).
This guide is intended for pharmaceutical manufacturers, medical-product companies, veterinary suppliers, institutional healthcare buyers, laboratories, distributors, and industrial formulators evaluating CAS 25655-41-8. It is also useful for procurement teams comparing bulk powder, ready-to-use solution, and customized povidone-iodine formulations. Each buyer may require different limits for available iodine, pH, viscosity, microbial quality, packaging, and shelf life. I use a documentation-first approach because the same CAS number can appear across different grades and product forms.
CAS 25655-41-8 is commonly associated with povidone-iodine, also known as iodopovidone. It is a complex formed from povidone, a water-soluble polymer, and iodine. The povidone component helps carry and solubilize iodine, while the iodine provides the antimicrobial function associated with the product.
Povidone-iodine should not be confused with elemental iodine, iodide salts, or povidone alone. These materials have different chemical identities, handling requirements, and application profiles. For this reason, I recommend checking the product name, CAS number, molecular description, available iodine specification, and formulation type together rather than relying on a single identifier.
Povidone-iodine is widely used as an active ingredient in antiseptic solutions, scrubs, swabs, and other topical preparations. Its use in a finished product depends on the target market, local regulations, product claims, and the manufacturer’s validated formulation. Buyers should distinguish between raw material supply and a legally marketed finished antiseptic product.
A frequently encountered formulation is a 10% solution with approximately 1% available iodine. This is a reference point, not a universal requirement, because commercial products may be supplied at other concentrations or in different vehicles. The final product must be assessed for stability, compatibility, packaging, and applicable regulatory requirements.
Veterinary products and institutional hygiene formulations may use povidone-iodine where an iodine-based antimicrobial ingredient is suitable. However, the acceptable concentration, label wording, contact instructions, and permitted use can vary significantly by country and application. A supplier should therefore receive the intended market and end use before recommending a grade.
Research laboratories may purchase povidone-iodine for formulation screening, analytical work, or process development. In these cases, a smaller package, defined assay range, and complete analytical documentation may be more important than the lowest bulk price. Buyers should confirm whether they need a raw complex, an aqueous solution, or another prepared form.
CAS 25655-41-8 may be supplied in different physical and formulation forms. Common purchasing categories include powder or solid complex, aqueous solution, and customized liquid preparation. These forms are not automatically interchangeable because concentration, viscosity, water content, packaging, and handling conditions can affect manufacturing performance.
| Specification Area | Why It Matters | What to Confirm |
|---|---|---|
| Available iodine | Indicates the iodine available for the intended function. | Assay method, target range, and batch result on the CoA. |
| Physical form | Affects dosing, dissolution, storage, and production equipment. | Powder, solution, viscosity, color, and homogeneity. |
| pH | Influences formulation stability and material compatibility. | Test conditions, acceptable range, and finished-product target. |
| Microbial quality | Important for healthcare and other controlled applications. | Applicable limits, test method, and responsibility for release testing. |
| Packaging and shelf life | Iodine-containing products may require protection from light and unsuitable materials. | Container type, storage conditions, retest or expiry information. |
Available iodine is one of the most important technical parameters. For some commonly marketed povidone-iodine products, the available iodine content is specified around 9–12% for the raw complex, while a 10% solution may be designed to provide about 1% available iodine. These values should be treated as common commercial references rather than a specification for every grade.
Color can also be a useful process indicator, but it should not replace analytical testing. A brown or reddish-brown appearance is often associated with iodine-containing products, while unexpected color changes may indicate formulation, storage, or compatibility issues. I advise buyers to define visual acceptance criteria together with assay, pH, viscosity, and stability requirements.
Start by stating whether the material is intended for a topical antiseptic, veterinary formulation, institutional product, laboratory use, or another application. Include the destination country because regulatory expectations and permitted claims may differ. This information allows the supplier to identify whether a standard grade or a specialized grade is appropriate.
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Determine whether your process requires a solid complex or a ready-to-use liquid. Powder may provide flexibility for in-house formulation, but it requires controlled weighing, dissolution, and process validation. Liquid material can simplify production, although its water content, viscosity, packaging volume, and transport conditions may increase total logistics costs.
Prepare a written specification covering available iodine, pH, appearance, viscosity where relevant, water content or solids content, microbial limits, heavy metals if applicable, and packaging. Do not accept a generic “povidone-iodine” description without confirming the actual grade. The supplier should explain which parameters are routinely tested and which are available only by agreement.
A professional supplier should be able to provide a current Safety Data Sheet (SDS), product specification, representative CoA, product description, packaging information, and storage recommendations. Depending on the market and application, buyers may also request a statement on allergens, residual solvents, animal-derived materials, elemental impurities, or other restricted substances. The exact document set should be agreed before purchase rather than after shipment.
The CoA should identify the product, batch or lot number, manufacturing or testing date where applicable, test methods, acceptance criteria, and actual results. I recommend checking that the CoA values correspond to the same grade and physical form described in the quotation. A document with only a pass statement may be insufficient for a buyer who needs to compare batches or support an internal release process.
The SDS is essential for hazard communication, safe handling, storage, and transport review. It should be consistent with the shipped material and the destination market’s requirements. Buyers should also confirm whether the product is classified for transport and whether the packaging is suitable for the selected route.
For regulated healthcare applications, additional documentation may be necessary. Examples can include a manufacturing statement, quality-system information, stability data, change-notification policy, or regulatory support package. I do not recommend assuming that a raw-material supplier’s documents automatically qualify a finished product for sale.
Pricing for CAS 25655-41-8 depends on grade, available iodine range, physical form, package size, order quantity, destination, and documentation requirements. A liquid solution may have a lower active-material concentration per kilogram than a solid complex, so buyers should compare cost on an active-iodine or finished-formulation basis where appropriate. Freight, hazardous-goods handling, temperature exposure, and import procedures can materially affect the delivered cost.
Minimum order quantity and lead time should be confirmed for both standard and customized specifications. Standard grades are generally easier to quote, while special packaging, private labeling, additional testing, or market-specific documents may require more coordination. I suggest requesting a quotation that separately lists product price, packaging, estimated lead time, payment terms, and any testing or documentation charges.
Before selecting a supplier, I recommend confirming five areas: product identity, technical consistency, documentation, logistics, and communication. The supplier should clearly state whether it supplies povidone-iodine as a solid complex, solution, or customized formulation. It should also explain its standard test items, batch-release process, packaging options, storage guidance, and response process for technical questions.
For ongoing supply, ask how specification changes are communicated and whether pre-shipment documents can be reviewed. If your process is sensitive to iodine loss, color, viscosity, or pH, request a sample or representative batch data before committing to a large order. These steps cannot replace your own qualification procedures, but they can reduce avoidable sourcing risk.
CAS 25655-41-8 is generally purchased as povidone-iodine for antiseptic, veterinary, institutional, or formulation-related applications. The right supplier is not simply the one offering the lowest price; it is the supplier that can match the required grade, provide traceable batch documentation, and support the buyer’s technical and regulatory review. I recommend beginning with a written specification and confirming whether you need solid povidone-iodine or a prepared solution.
To request a B2B quotation from Yuking, prepare your target application, destination country, required available iodine range, physical form, package size, estimated quantity, and documentation list. We can then review the inquiry against the requested specification and clarify which documents and samples are available for evaluation. This structured approach gives your procurement and quality teams a clearer basis for qualification and long-term supply planning.
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