Antiparasitic Agents

04 Feb.,2024

 

IvermectinAn anti parasite medication used to treat head lice, onchocerciasis, strongyloidiasis, ascariasis, trichuriasis, and enterobiasis.PyrimethamineAn antiparasitic drug used in the prevention and treatment of toxoplasmosis and malaria.DapsoneA sulfone drug used to treat acne vulgaris, Hansen's disease, and dermatitis herpetiformis.DoxycyclineA tetracycline antibiotic used to treat a wide variety of bacterial infections.MefloquineAn antimalarial agent used in the prophylaxis and treatment of malaria caused by Plasmodium falciparum and Plasmodium vivax.SulfadiazineA sulfonamide antibiotic used in a variety of infections, such as urinary tract infections, trachoma, and chancroid.QuinineAn alkaloid used to treat uncomplicated Plasmodium falciparum malaria.NitazoxanideA thiazolide anti-infective used to treat infections by protozoa, helminths, anaerobic bacteria, microaerophilic bacteria, and viruses.AlbendazoleA benzimidazole anthelmintic used to treat parenchymal neurocysticercosis and other helminth infections.PiperazineA medication used to treat roundworm and pinworm.AmodiaquineAn antimalarial drug.FurazolidoneA drug for the treatment of infectious diarrhea.MebendazoleA benzimidazole anthelmintic used to treat helminth infections.SulfametopyrazineAn antibiotic used in the treatment or prevention of bacterial infections and malaria.Amphotericin BAn antifungal used to treat fungal infections in neutropenic patients, cryptococcal meningitis in HIV infection, fungal infections, and leishmaniasis.DiethylcarbamazineAn anthelmintic used to treat filarial infections like Wuchereria bancrofti and Loa loa.ThiabendazoleA benzimidazole used in the treatment of strongyloides, cutaneous larva migrans, visceral larva migrans, and trichinosis infections.PentamidineAn antifungal agent used to treat Pneumocystis pneumonia in patients infected with HIV.LevamisoleLevamisole is a nicotinic receptor agonist used to treat helminth infections and some skin infections.QuinidineA medication used to restore normal sinus rhythm, treat atrial fibrillation and flutter, and treat ventricular arrhythmias.TinidazoleA nitroimidazole used to treat trichomoniasis, giardiasis, amebiasis, and bacterial vaginosis.MetronidazoleA nitroimidazole used to treat trichomoniasis, amebiasis, inflammatory lesions of rosacea, and bacterial infections, as well as prevent postoperative infections.PraziquantelAn anthelmintic medication used to treat a number of parasitic worm infections such as schistosomiasis.PrimaquineAn antimalarial indicated to prevent relapse of vivax malaria.OxamniquineFor treatment of Schistosomiasis caused by Schistosoma mansoniAtovaquoneAn antimicrobial indicated for the prevention and treatment of Pneumocystis jirovecii pneumonia (PCP) and for the prevention and treatment of Plasmodium falciparum malaria.ProguanilA medication indicated for prophylaxis and treatment of Plasmodium falciparum malaria.HalofantrineAn antimalarial used for the treatment of severe malaria.PosaconazoleA triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients.SulfadoxineA long acting sulfonamide used for the treatment or prevention of malaria.ParomomycinAn aminoglycoside antibiotic used in the treatment of acute and chronic intestinal amebiasis, and as an adjunct for the management of hepatic coma.HydroxychloroquineAn antimalarial medication used to treat uncomplicated cases of malaria and for chemoprophylaxis in specific regions. Also a disease modifying anti-rheumatic drug (DMARD) indicated for treatment of rheumatoid arthritis and lupus erythematosus.SinefunginSinefungin is a solid. This compound belongs to the purine nucleosides and analogues. These are compounds comprising a purine base attached to a sugar. The proteins that adenosyl-ornithine target include...5'-S-methyl-5'-thioadenosine

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Fumagillin

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Benzimidazole

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DiminazeneDiminazene, also known as Diminazine, 4,4'-(Diazoamino)benzamidine, 4,4'-(1-triazene-1,3-diyl)bis-benzenecarboximidamide, diminazine aceturate, or Diminazene aceturate, is a trypanocidal agent. Major brands of Diminazene are Berenil, Pirocide, Ganasag, and Azidin. This substance is a...Radicicol

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Salicylhydroxamic Acid

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GeneticinGeneticin (also known as G418) is an aminoglycoside antibiotic similar in structure to gentamicin B1, produced by Micromonospora rhodorangea. Geneticin blocks polypeptide synthesis by inhibiting the elongation step in both...BithionolBithionol, formerly marketed as an active ingredient in various topical drug products, was shown to be a potent photosensitizer with the potential to cause serious skin disorders. Approvals of the...HalofuginoneFor the treatment of scleroderma, cancer, and restenosis.OxibendazoleInvestigated for use/treatment in infectious and parasitic disease (unspecified) and pediatric indications.LucanthoneIntended for use as a radiation sensitizer in the treatment of brain cancer.AndrographolideInvestigated for use/treatment in ulcerative colitis.SpiramycinA macrolide antimicrobial agent used in the treatment of various bacterial infections.EflornithineAn ornithine decarboxylase inhibitor used to prevent relapse of high-risk neuroblastoma in pediatric and adult patientsLonidamineInvestigated for use/treatment in benign prostatic hyperplasia, prostate disorders, and cancer/tumors (unspecified).TafenoquineAn antiparasitic agent used for the treatment and prevention of relapse of Vivax malaria.LumefantrineAn antimalarial agent used in combination with artemether for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum.NiclosamideAn anthelmintic indicated in the treatment of beef, pork, fish, and dwarf tapeworm infections in adults and children.PyrviniumAn anthelmintic agent used for the treatment of pinworm infestations.AnisomycinAnisomycin (sometimes known as flagecidin), is an antibiotic retrieved from the bacteria Streptomyces griseolus. This drug acts to inhibit bacterial protein and DNA synthesis.PuromycinPuromycin is an antibiotic that prevents bacterial protein translation. It is utilized as a selective agent in laboratory cell cultures. Puromycin is toxic to both prokaryotic and eukaryotic cells, resulting...DiloxanideDiloxanide is used alone as a primary agent in the treatment of asymptomatic (cyst passers) intestinal amebiasis caused by Entamoeba histolytica. Diloxanide may also be used concurrently, or sequentially, with...FlubendazoleFlubendazole is an anthelmintic that is used to treat worm infection in humans. It is available OTC in Europe.MiltefosineAn antileishmanial agent used to treat leishmaniasis, a group of disease caused by parasites of the Leishmania type.ChlortetracyclineThe first tetracycline antibiotic most commonly used for veterinary purposes.DiiodohydroxyquinolineUsed in the treatment of amoebiasis.ArtesunateArtesunate is an artemesinin derivative indicated for the initial treatment of severe malaria.PyrantelAn anthelmintic used to treat helminth infections.HexylresorcinolAn ingredient used to relieve irritation, pain, and prevent infection.AmproliumAmprolium is a coccidiostat used in poultry.Cambendazole

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Clorsulon

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CoumaphosThis drug is a fat-soluble phosphorothioate agent that kills both insects and mites. It is non-volatile in nature and is well known by a variety of names as such a...DecoquinateDecoquinate is used in veterinary to delay the growth and reproduction of coccidian parasites.DichlorophenDichlorophen is an antimicrobial agent shown to exert activity against cestodes, protozoa, fungi, and bacteria. It is often combined with toluene to remove parasites including ascarids, tapeworm, and hookworm from...DichlorvosDichlorvos or 2,2-dichlorovinyl dimethyl phosphate is a drug of the organophosphate class, frequently used as an insecticide for the control of indoor pests and for the protection of stored products...DiclazurilDiclazuril is a coccidiostat.DoramectinDoramectin is a veterinary drug approved by the Food and Drug Administration for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites in...Eprinomectin

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Febantel

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FenbendazoleFenbendazole is a benzimidazole that presents a wide spectrum anthelmintic effect. It is used against a number of gastrointestinal parasites including giardia, roundworms, hookworms, whipworms, the Taenia genus of tapeworms,...LasalocidLasalocid is an agent that presents antibacterial and coccidiostat activities. It is produced by strains of Streptomyces lasaliensis.MonensinMonensin is a polyether isolated from Streptomyces cinnamonensis that presents antibiotic properties. It is widely used in ruminant animal feeds.MoxidectinMoxidectin is indicated for the treatment of river blindness, also called onchocerciasis, in patients aged 12 years and older. River blindness is caused by a parasitic worm Onchocerca volvulus and...NarasinNarasin is an agent with coccidiostatic and antibacterial properties.Nicarbazin

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OxfendazoleOxfendazole is a sulfoxide metabolite of fenbendazole. This benzimidazole antihelminthic protects livestock from roundworm. strongyles, and pinworn.PhenothiazinePhenothiazine (PTZ) is an organic thiazine compound.RoxarsoneRoxarsone is an organoarsenic molecule added to poultry feed. The addition of this compound to poultry feed improves weight gain and feed efficiency as well as prevent the growth of...SelamectinSelamectin is a topical parasiticide and antihelminthic used on dogs and cats to treat and prevent infections of heartworms, fleas, ear mites, sarcoptic mange, and certain types of ticks in...SulfaquinoxalineSulfaquinoxaline is a veterinary medicine which can be given to cattle and sheep to treat coccidiosis.It is available in Pakistan with Sanna Laboratories in combination with Amprolium and Vitamin K...MetrifonateMetrifonate or trichlorfon is an irreversible organophosphate acetylcholinesterase inhibitor. It is a prodrug which is activated non-enzymatically into 2,2-dichlorovinyl dimethyl phosphate.ZoaleneDinitolmide is a fodder additive for prophylaxis against coccidiosis infections in poultry.BunamidineBunamidine is a veterinary anti-platyhelmintic agent used for taenia infestations.DithiazanineDithiazanine is a highly potent anthelmintic, introduced in 1959 for the treatment of strongyloid worms and whipworms. However, its use is severely limited due to its toxicity. Dithiazanine iodide was...Hygromycin BHygromycin B is an aminoglycoside antibiotic produced by the bacterium Streptomyces hygroscopicus which kills bacteria, fungi and higher eukaryotic cells by inhibiting protein synthesis.ImidocarbImidocarb is a urea derivative used in veterinary medicine as an antiprotozoal agent for the treatment of infection with Babesia and other parasites.Milbemycin oxime

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RobenidineRobenidine is identified as a coccidiostat drug, which slows both the growth and reproductive cycles of coccidian parasites. Robenidine is used to control coccidiosis, a lethal infection in poultry which...Salinomycin

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ArtenimolFor the treatment of uncomplicated Plasmodium falciparum infection in adults, children, and infants aged 6 months and up weighing over 5 kg [FDA Label]. Used in combination with DB13941.MisonidazoleMisonidazole is under investigation in clinical trial NCT00038038 (Assessment of Head and Neck Tumor Hypoxia Using 18F-Fluoromisonidazole).NifurtimoxAn antiparasitic drug used for the treatment of Chagas disease (Trypanosoma cruzi infection).BenznidazoleA trypanocidal agent used to treat Chagas disease.NimorazoleNimorazole has been used in trials studying the treatment of Hypoxia, Radiotherapy, Hypoxic Modification, Gene Profile, Gene Signature, and Head and Neck Squamous Cell Carcinoma, among others.TriclabendazoleAn anthelmintic drug used to treat fascioliasis.ChlorproguanilChlorproguanil has been used in trials studying the treatment of MALARIA. It is a dichloro-derivative of chloroguanide.OltiprazOltipraz has been used in trials studying the treatment and prevention of Lung Cancer, Liver Fibrosis, Liver Cirrhosis, and Non-alcoholic Fatty Liver Disease.MizoribineMizoribine has been investigated for the treatment of Rheumatoid Arthritis.SecnidazoleA nitroimidazole antibiotic used to treat bacterial vaginosis.MelarsoprolMelarsoprol is under investigation in clinical trial NCT00330148 (Randomized Clinical Trial of Three Drug Combinations for Late-Stage Gambiense Human African Trypanosomiasis).PyronaridineA benzonaphthyridine derivative indicated in the treatment of acute malaria caused by P. falciparum or P. vivax in area with low rates of infection and low resistance to artemisinin.CarbendazimCarbendazim has been used in trials studying the treatment of Lymphoma and Unspecified Adult Solid Tumor, Protocol Specific.OrnidazoleA nitroimidazole agent indicated in the treatment of infections such as trichomoniasis, amebiasis, and giardiasis.EtofamideEtofamide is used as an antiamoebic agent. Etofamide, under the brand name Kitnos, was marketed in Brazil by Pfizer but has been discontinued .Propamidine

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MepartricinA medication indicated in the treatment of benign prostatic hyperplasia, vaginal candidiasis, or trichomoniasis.Niridazole

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OxantelAn antihelminthic indicated in the treatment of ascaris, trichocephaliasis, and oxyuriasis infections.NifuratelA nitrofuran derivative indicated in the treatment of leucorrhea, vulvovaginal infections, and urinary tract infections.Meglumine antimoniate

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Albendazole oxide

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PiperaquineFor the treatment of uncomplicated Plasmodium falciparum infection in adults, children, and infants aged 6 months and up weighing over 5 kg [FDA Label]. Used in combination with DB11638.StibophenStibophen is used in the treatment of schistosomiasis, a disease of parasitic flatworms.Bephenium

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Ciclobendazole

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Desaspidin

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Hachimycin

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ChloroquineAn antimalarial drug used to treat susceptible infections with P. vivax, P. malariae, P. ovale, and P. falciparum. It is also used for second line treatment for rheumatoid arthritis.QuinacrineFor the treatment of giardiasis and cutaneous leishmaniasis and the management of malignant effusions.SuraminFor treatment of human sleeping sickness, onchocerciasis and other diseases caused by trypanosomes and worms.Sodium stibogluconateFor the treatment of various types of a protozoal infection called leishmaniasis, which may result from sandfly bites in tropical and temperate parts of the world. Also investigated for use/treatment...ArtemetherAn antimalarial agent used in combination with lumefantrine for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum.ChloroxylenolAn antimicrobial used to treat cuts, bites, stings, abrasions, and used as an antiseptic hand cleaner.Emetine

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ArtemotilArtemotil, also known as β-arteether, is a semi-synthetic derivative of artemisinin and a fast acting blood schizonticide specifically indicated for the treatment of chloroquine-resistant Plasmodium falciparum malaria and cerebral malaria...HycanthonePotentially toxic, but effective antischistosomal agent, it is a metabolite of LUCANTHONE. Hycanthone was approved by the FDA in 1975 but is no longer used.Tetrandrine

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Diloxanide furoateDiloxanide is used alone as a primary agent in the treatment of asymptomatic (cyst passers) intestinal amebiasis caused by Entamoeba histolytica. Diloxanide may also be used concurrently, or sequentially, with...Betulinic AcidBetulinic Acid has been used in trials studying the treatment of Dysplastic Nevus Syndrome.CycloguanilCycloguanil is the active metabolite of proguanil.PafuramidineInvestigated for use/treatment in pneumonia, trypanosomiasis, malaria, HIV infection, and infectious and parasitic disease (unspecified).EmodepsideEmodepside is an anthelmintic drug that is effective against a number of gastrointestinal nematodes, is licensed for use in cats and belongs to the class of drugs known as the...ArtefenomelArtefenomel has been investigated for the treatment of Malaria.Antimony potassium tartrateAntimony potassium tartrate is a schistosomicide possibly useful against other parasites. It has irritant emetic properties and may cause lethal cardiac toxicity among other adverse effects.HomidiumHomidium is a group II compound with trypanocidal effects.PlumbaginPlumbagin is a compound investigated for its anticancer activity. It has been found that it inactivates the Akt/NF-kB, MMP-9 and VEGF pathways.Allopurinol ribosideAllopurinol riboside is a nucleoside analogue of allopurinol with a beta-D-ribofuranosyl moiety at the 1-position.LotilanerAn antiparasitic agent used to treat Demodex blepharitis.Psoralen

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