4-Bromophenylboronic acid, CAS 5467-74-3, is a bifunctional aryl boronic acid used mainly as a building block in cross-coupling chemistry and pharmaceutical, agrochemical, and advanced-material research. Its molecular formula is C6H6BBrO2, and its reported molecular weight is 200.83 g/mol. The molecule combines a boronic acid group with a para-bromo substituent, giving chemists two useful reaction handles for planned synthesis.
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At Maison Chemical, I recommend evaluating this material through four criteria: identity, purity, physical form, and supply consistency. Buyers should confirm the required specification, analytical documentation, packaging, and expected lead time before placing an order. This guide explains the material’s role, common applications, selection considerations, and practical steps for sourcing it responsibly.
This guide is intended for procurement teams, process chemists, R&D scientists, custom synthesis organizations, and distributors evaluating 4-Bromophenylboronic acid for laboratory or manufacturing use. It is also useful for buyers comparing catalog material with a supplier-supported sourcing program. The most important point is that the right grade depends on the reaction, scale, impurity tolerance, and documentation requirements of the project.
I do not recommend selecting a supplier based only on a product name or a single advertised purity number. A suitable supplier should be able to clarify the product identity, available quantity, packaging options, analytical support, and commercial terms. For regulated or scale-sensitive projects, these details can be as important as the nominal chemical structure.
4-Bromophenylboronic acid is an aryl boronic acid in which the boronic acid group and bromine atom are positioned para to each other on a benzene ring. The boronic acid functionality is commonly used in palladium-catalyzed Suzuki-Miyaura coupling with suitable aryl or vinyl halides. The aryl bromide functionality may also serve as a second transformation site, depending on the selected reaction conditions and synthetic sequence.
This combination makes the compound valuable for convergent synthesis. A chemist may use the boronic acid group in one coupling step while retaining the aryl bromide for a later functionalization, or may use the bromine substituent as the primary reaction site in another route. Actual reactivity depends on catalyst, base, solvent, temperature, substrate compatibility, and water content, so I recommend confirming performance at the project-specific scale.
| Parameter | Information |
|---|---|
| Product name | 4-Bromophenylboronic acid |
| CAS number | 5467-74-3 |
| Molecular formula | C6H6BBrO2 |
| Reported molecular weight | 200.83 g/mol |
| Functional groups | Aryl boronic acid and aryl bromide |
These identity points should be consistent across the quotation, specification, certificate of analysis, safety data sheet, and shipping documents. If a project requires a specific solid form, water content, residual solvent limit, or analytical method, those requirements should be discussed before order confirmation rather than assumed from the CAS number alone.
In medicinal chemistry, 4-Bromophenylboronic acid can support the preparation of substituted biaryl, heteroaryl, and related aromatic structures. Its value comes from the ability to introduce a para-substituted phenyl fragment through cross-coupling. Researchers may use it in analog development, route scouting, and small-scale structure-activity relationship studies.
The material is generally selected when the target structure benefits from a 4-bromophenyl-derived unit or when a sequential synthetic route is being considered. I recommend checking whether the bromine atom must remain available after coupling, because the preferred reaction order can affect yield, selectivity, and downstream purification.
Aryl boronic acids are also used in the discovery and preparation of specialty organic molecules, including intermediates for agrochemical and functional-material research. 4-Bromophenylboronic acid may be relevant when a para-brominated aromatic intermediate is required for further derivatization. Its suitability should be assessed against the target structure and the project’s process safety requirements.
Research groups developing conjugated molecules, ligands, and aromatic materials may use this compound as a modular intermediate. The two reaction handles can help build more complex architectures through sequential or selective transformations. However, not every materials route benefits from a boronic acid intermediate, so buyers should compare it with a direct aryl halide, a protected boronate ester, or another functionalized aromatic starting material.
The free boronic acid is often convenient for direct Suzuki-Miyaura coupling, while protected boronate esters may offer different handling or storage behavior in some synthetic workflows. The best choice depends on reaction conditions, hydrolytic stability, purification strategy, and downstream compatibility. I advise buyers to compare the complete route rather than treating the free acid and an ester as interchangeable products.
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For early discovery work, buyers may focus on chemical identity and a suitable assay specification. For process development, they may additionally require related-substance limits, water content, residual solvents, elemental impurities, particle characteristics, and a defined analytical method. A supplier should confirm which tests are included in the routine certificate of analysis and which tests require a special request.
When screening suppliers, I suggest requesting representative documentation before committing to a larger quantity. A buyer can begin with a 1 g or 100 g evaluation quantity for route development, then request a 1 kg quotation if the process advances. These quantities are purchasing examples, not a guarantee of available stock, and actual pack sizes should be confirmed with Maison Chemical.
The price of 4-Bromophenylboronic acid can vary with quantity, specification, packaging, production status, analytical requirements, and destination. Small research quantities usually have a different cost structure from manufacturing quantities because packaging and documentation represent a larger portion of the transaction. I recommend requesting tiered pricing rather than evaluating a single pack size.
Minimum order quantity and lead time should also be confirmed in writing. In-stock material, scheduled production, and made-to-order material can have different delivery expectations, and export documentation may add additional time. Maison Chemical can review the requested quantity, destination, specification, and target delivery window to prepare a more appropriate quotation.
These questions help separate a simple product listing from a practical B2B supply solution. They also reduce the risk of receiving material that matches the name but not the project’s analytical or logistical requirements.
I recommend checking whether the supplier can discuss the chemistry clearly and distinguish 4-Bromophenylboronic acid from related positional isomers, protected boronates, and other brominated aromatic intermediates. Product identity should be traceable through consistent documentation. If the project is moving toward scale, ask how the supplier manages batch records, change communication, and specification alignment.
A capable export supplier should communicate clearly about packaging, labeling, transport documentation, payment terms, and destination requirements. These details are especially important for international procurement because the chemical quotation is only one part of the total supply process. Buyers should also confirm whether the proposed quantity is available immediately or requires production scheduling.
At Maison Chemical, I support B2B inquiries by reviewing the requested grade, quantity, intended use, destination, and documentation needs before preparing a quotation. Depending on the project, we can discuss standard supply, evaluation quantities, larger-volume planning, and reasonable analytical or packaging requirements. Specific availability and terms must be confirmed for each inquiry.
One common mistake is selecting material solely by CAS number without reviewing the specification and certificate of analysis. Another is assuming that a laboratory-grade product automatically meets process-development or manufacturing requirements. Buyers should also avoid comparing prices without considering pack size, testing scope, lead time, shipping terms, and the cost of qualification.
A further mistake is overlooking the reaction sequence. Because this molecule contains both an aryl bromide and a boronic acid group, the planned order of transformations may influence the appropriate material and process conditions. Discussing the synthetic route at a high level can help the supplier understand whether standard material, special testing, or an alternative intermediate should be considered.
4-Bromophenylboronic acid CAS 5467-74-3 is a useful synthetic building block when a route requires the reactivity of an aryl boronic acid together with a para-bromo substituent. The best purchasing decision depends not only on the chemical name, but also on the required purity, analytical evidence, scale, packaging, and delivery conditions. I recommend starting with a clear specification and matching the supplier to the project’s technical and commercial needs.
As a next step, send Maison Chemical your required quantity, intended application, target specification, destination, and documentation expectations. We can then review suitable supply options, confirm current availability and lead time, and prepare a B2B quotation for evaluation or scale-up. This approach gives your team a practical basis for qualifying 4-Bromophenylboronic acid before committing to larger procurement.
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