1,4-Cyclohexanedione monoethylene acetal, also called 1,4-cyclohexanedione monoethylene ketal, is a protected cyclohexanedione intermediate identified by CAS Registry Number 4746-97-8. Its commonly reported molecular formula is C8H12O3, with a relative molecular mass of approximately 156.18 g/mol. Buyers generally evaluate this material as a synthetic building block for pharmaceutical, fine chemical, and research applications, while confirming identity, purity, residual solvents, water content, packaging, and documentation before purchase.
At Maison Chemical, I recommend qualifying this product through a specification review, a representative Certificate of Analysis, a Safety Data Sheet, sample evaluation, and a clear discussion of intended use. The correct purchasing decision depends not only on the CAS number, but also on the required quality grade, analytical method, packaging size, delivery destination, and regulatory documentation.
This guide is intended for pharmaceutical intermediate buyers, process development teams, medicinal chemistry laboratories, fine chemical manufacturers, distributors, and procurement professionals sourcing 1,4-cyclohexanedione monoethylene acetal. It is particularly useful when a buyer needs to compare multiple suppliers or convert a laboratory requirement into a repeatable commercial specification.
The guide also supports buyers who need to distinguish between a research-scale purchase and a production-oriented supply program. A material that is suitable for an initial synthesis may require additional controls before it is introduced into a regulated or quality-sensitive process. I therefore recommend treating supplier qualification as a technical and commercial review rather than as a price-only comparison.
1,4-Cyclohexanedione monoethylene acetal contains a cyclic ketal protecting group and a remaining ketone functionality. This structure makes it useful as an intermediate when a synthetic route requires selective protection of one carbonyl group while retaining another reactive site for subsequent transformation.
The commonly reported formula is C8H12O3, and the approximate molecular weight is 156.18 g/mol. These values should be checked against the supplier’s current product specification and analytical documentation because database entries, naming conventions, and commercial specifications may differ in presentation.
For an independent identity check, buyers can consult the U.S. National Library of Medicine PubChem database and compare the reported chemical information with the supplier’s SDS and CoA. PubChem is a useful reference, but it does not replace lot-specific testing or a supplier-issued quality document.
Research-grade material is commonly purchased in quantities such as 1 g, 5 g, 25 g, or 100 g, depending on the supplier and project stage. This option may be appropriate for route scouting, method development, medicinal chemistry, and small-scale feasibility work. Buyers should still request a CoA showing the actual lot number, assay or purity result, analytical method, and date of manufacture or release.
Process-oriented procurement usually requires a more detailed specification than a small laboratory purchase. Typical review points include assay, related substances, water, residual solvents, appearance, identity, batch-to-batch consistency, retest period, and packaging controls. The required limits should be agreed before quotation because “high purity” is not a sufficiently precise commercial specification.
Some buyers need special packaging, a defined residual-solvent profile, additional analytical data, or a supply plan covering multiple batches. These requirements should be discussed before order confirmation because they can affect manufacturing scheduling, testing, documentation, and minimum order quantity. Maison Chemical can review project-specific requirements and indicate which items can be supported based on the requested grade and destination market.
1,4-Cyclohexanedione monoethylene acetal is mainly considered an organic synthesis intermediate and protected carbonyl building block. Its potential use includes pharmaceutical intermediate synthesis, fine chemical preparation, process research, and laboratory-scale route development. The actual suitability depends on the reaction sequence, downstream impurity tolerance, reaction conditions, and the buyer’s internal quality requirements.
In a synthetic route, the ketal group may help control the reactivity of one carbonyl position while the remaining ketone participates in subsequent transformations. This can be relevant in carbon–carbon bond formation, functional-group interconversion, and preparation of more advanced cyclic intermediates. I recommend confirming compatibility through a small-scale evaluation rather than assuming that a published reaction will perform identically with every commercial lot.
| Buyer Requirement | Information to Confirm | Why It Matters |
|---|---|---|
| Route scouting | Identity, purity, available package sizes | Supports rapid feasibility testing and sample planning |
| Process development | Assay, related substances, water, residual solvents | Helps assess downstream process risk |
| Commercial sourcing | Batch consistency, lead time, packaging, change control | Supports supply continuity and manufacturing planning |
| Regulated project | SDS, CoA, traceability, regulatory statements | Enables internal quality and compliance review |
The U.S. National Library of Medicine’s Guide to Chemical Hazards explains why chemical handling and hazard communication should be based on documented substance information. For this product, buyers should obtain the current SDS, review storage and handling instructions, and ensure that their own occupational safety team evaluates the material before use.
Begin with the product name, CAS number 4746-97-8, molecular formula, molecular weight, and an identity method such as NMR, IR, GC-MS, or another method suitable for the material. The supplier should clearly state which identity tests are performed and whether the reported result is for the shipped lot. A CAS number alone does not establish purity, grade, or manufacturing consistency.
Ask whether purity is measured by HPLC, GC, NMR, or another validated or qualified method. The specification should state the acceptance limit, for example “not less than” a defined percentage, rather than using an undefined term such as “premium grade.” Related substances may be especially important when the material enters a multi-step pharmaceutical synthesis, because low-level impurities can accumulate or complicate downstream purification.
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Water content may affect moisture-sensitive reactions, while residual solvents can influence reaction performance, safety review, and downstream purification. Ask for the analytical method and reporting unit, such as percentage, ppm, or mg/kg, rather than relying on a general statement that the product is dry. Also confirm whether the supplied material is a solid, liquid, or material with a defined appearance at the stated storage temperature.
Packaging should be selected according to the quantity, shipping method, exposure risk, and intended storage period. Buyers may need to compare 25 g laboratory packs, 1 kg development quantities, or larger commercial packages, but actual availability must be confirmed with the supplier. The SDS and product label should state handling and storage conditions, and the receiving site should verify container integrity when the shipment arrives.
Before requesting quotations, specify whether the material is for research, process development, registration support, or routine production. Record the target quantity, required purity, permitted impurity profile, delivery location, packaging preference, and requested documentation. This information allows suppliers to provide comparable offers instead of broad and difficult-to-evaluate price indications.
At minimum, request a current CoA and SDS for the proposed product. For a quality-sensitive project, also ask about analytical methods, sample availability, manufacturing location, batch traceability, retest policy, change notification, and export documentation. If the supplier cannot explain how the reported specification is measured, the buyer should treat the quality information as incomplete.
Where practical, obtain a representative sample before placing a larger order. Compare the sample’s appearance, analytical profile, reaction performance, and impurity behavior with the project’s internal requirements. A sample evaluation does not guarantee future batch equivalence, so the commercial discussion should also address batch consistency and acceptance criteria.
Price should be assessed together with quantity, packaging, shipping terms, payment terms, lead time, documentation, and replacement policy. A lower unit price may not be advantageous if the minimum order quantity is too large or if the delivery schedule does not match the production plan. Ask whether the quoted lead time is based on available stock, scheduled production, or a new manufacturing campaign.
There is no responsible universal price for CAS 4746-97-8 because cost can vary with purity, package size, order quantity, destination, testing requirements, and market conditions. Small laboratory packages generally have a higher price per gram than larger quantities, while custom specifications may add testing or scheduling costs. Buyers should request a quotation based on a defined quantity, such as 100 g, 1 kg, or a project-specific amount.
Minimum order quantity and lead time should be confirmed in writing before purchase. Stock availability can change, and a supplier may quote different timelines for a sample, a standard batch, and a repeat commercial order. I recommend asking for both the current delivery estimate and the expected timeline for a repeat order so that procurement can assess continuity risk.
For international sourcing, include freight classification, export documents, import requirements, customs clearance, insurance, and temperature or moisture considerations where relevant. The United Nations Recommendations on the Transport of Dangerous Goods provide an authoritative framework for dangerous-goods transport information, although the transport classification for a specific shipment must be confirmed from the current SDS and applicable regulations.
One common mistake is selecting a product solely by CAS number and advertised purity. The CAS number identifies the substance, but it does not define the complete analytical profile, manufacturing process, packaging, or documentation package. Another mistake is comparing quotations that use different purity methods or different quantities without normalizing the commercial terms.
Buyers should also avoid postponing documentation review until after shipment. If the project requires a specific residual-solvent limit, water limit, or analytical method, that requirement should be discussed before the supplier prepares the quotation. Finally, do not assume that a laboratory sample automatically represents future production batches without a clear quality and supply agreement.
Maison Chemical supports buyers evaluating 1,4-cyclohexanedione monoethylene acetal for pharmaceutical intermediate and fine chemical applications. I can help organize a product inquiry around the required quantity, specification, packaging, destination, and documentation package. This approach makes it easier to determine whether a standard supply option or a project-specific arrangement is more appropriate.
For an efficient quotation review, send the requested quantity, target purity, intended application, preferred package size, delivery country, and any special requirements for CoA, SDS, residual solvents, water, or traceability. I can then review the request according to the available product information and provide a commercially relevant response without assuming requirements that have not been confirmed. Final suitability should remain subject to the buyer’s own technical, regulatory, and safety approval.
The right way to buy 1,4-cyclohexanedione monoethylene acetal CAS 4746-97-8 is to match the material specification with the intended synthesis and then qualify the supplier’s documentation, consistency, service, and delivery capability. Start by defining the required purity and analytical limits, request a lot-specific CoA and SDS, evaluate a sample when appropriate, and confirm MOQ and lead time in writing. This process reduces the risk of selecting a product that meets the name on the label but not the needs of the process.
Maison Chemical can support your evaluation as a chemicals and pharmaceutical intermediates supplier. To request current availability or a quotation, provide your target quantity, required specification, packaging preference, destination, and documentation needs. I will use those details to help identify the most suitable supply route for your project.
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